MicroRNAs’ Involvement in Osteoarthritis and the Prospects for Treatments
Joint Authors
Peng, Jiang
Wang, Ai-Yuan
Meng, Hao-Ye
Yu, Xiao-Ming
Guo, Quan-Yi
Lu, Shi-Bi
Wang, Yu
Yuan, Xue-Ling
Source
Evidence-Based Complementary and Alternative Medicine
Issue
Vol. 2015, Issue 2015 (31 Dec. 2015), pp.1-13, 13 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2015-10-26
Country of Publication
Egypt
No. of Pages
13
Main Subjects
Abstract EN
Osteoarthritis (OA) is a chronic disease and its etiology is complex.
With increasing OA incidence, more and more people are facing heavy financial and social burdens from the disease.
Genetics-related aspects of OA pathogenesis are not well understood.
Recent reports have examined the molecular mechanisms and genes related to OA.
It has been realized that genetic changes in articular cartilage and bone may contribute to OA’s development.
Osteoclasts, osteoblasts, osteocytes, and chondrocytes in joints must express appropriate genes to achieve tissue homeostasis, and errors in this can cause OA.
MicroRNAs (miRNAs) are small noncoding RNAs that have been discovered to be overarching regulators of gene expression.
Their ability to repress many target genes and their target-binding specificity indicate a complex network of interactions, which is still being defined.
Many studies have focused on the role of miRNAs in bone and cartilage and have identified numbers of miRNAs that play important roles in regulating bone and cartilage homeostasis.
Those miRNAs may also be involved in the pathology of OA, which is the focus of this review.
Future studies on the role of miRNAs in OA will provide important clues leading to a better understanding of the mechanism(s) of OA and, more particularly, to the development of therapeutic targets for OA.
American Psychological Association (APA)
Yu, Xiao-Ming& Meng, Hao-Ye& Yuan, Xue-Ling& Wang, Yu& Guo, Quan-Yi& Peng, Jiang…[et al.]. 2015. MicroRNAs’ Involvement in Osteoarthritis and the Prospects for Treatments. Evidence-Based Complementary and Alternative Medicine،Vol. 2015, no. 2015, pp.1-13.
https://search.emarefa.net/detail/BIM-1061264
Modern Language Association (MLA)
Yu, Xiao-Ming…[et al.]. MicroRNAs’ Involvement in Osteoarthritis and the Prospects for Treatments. Evidence-Based Complementary and Alternative Medicine No. 2015 (2015), pp.1-13.
https://search.emarefa.net/detail/BIM-1061264
American Medical Association (AMA)
Yu, Xiao-Ming& Meng, Hao-Ye& Yuan, Xue-Ling& Wang, Yu& Guo, Quan-Yi& Peng, Jiang…[et al.]. MicroRNAs’ Involvement in Osteoarthritis and the Prospects for Treatments. Evidence-Based Complementary and Alternative Medicine. 2015. Vol. 2015, no. 2015, pp.1-13.
https://search.emarefa.net/detail/BIM-1061264
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1061264