![](/images/graphics-bg.png)
NaoXinTong Inhibits the Development of Diabetic Retinopathy in dbdb Mice
المؤلفون المشاركون
Liu, Mengyang
Pan, Quan
Chen, Yuanli
Yang, Xiaoxiao
Zhao, Buchang
Jia, Lifu
Zhu, Yan
Han, Jihong
Li, Xiaoju
Duan, Yajun
المصدر
Evidence-Based Complementary and Alternative Medicine
العدد
المجلد 2015، العدد 2015 (31 ديسمبر/كانون الأول 2015)، ص ص. 1-8، 8ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2015-03-03
دولة النشر
مصر
عدد الصفحات
8
التخصصات الرئيسية
الملخص EN
Buchang NaoXinTong capsule (NXT) is a Chinese Materia Medica standardized product extracted from 16 Chinese traditional medical herbs and widely used for treatment of patients with cerebrovascular and cardiovascular diseases in China.
Formation of microaneurysms plays an important role in the development of diabetic retinopathy.
In this study, we investigated if NXT can protect diabetic mice against the development of diabetic retinopathy.
The db/db mice (~6 weeks old), a diabetic animal model, were divided into two groups and fed normal chow or plus NXT for 14 weeks.
During the treatment, fasting blood glucose levels were monthly determined.
After treatment, retinas were collected to determine retinal thickness, accumulation of carbohydrate macromolecules, and caspase-3 (CAS-3) expression.
Our results demonstrate that administration of NXT decreased fasting blood glucose levels.
Associated with the decreased glucose levels, NXT blocked the diabetes-induced shrink of multiple layers, such as photoreceptor layer and outer nuclear/plexiform layers, in the retina.
NXT also inhibited the diabetes-induced expression of CAS-3 protein and mRNA, MMP-2/9 and TNFα mRNA, accumulation of carbohydrate macromolecules, and formation of acellular capillaries in the retina.
Taken together, our study shows that NXT can inhibit the development of diabetic retinopathy and suggests a new potential application of NXT in clinic.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Liu, Mengyang& Pan, Quan& Chen, Yuanli& Yang, Xiaoxiao& Zhao, Buchang& Jia, Lifu…[et al.]. 2015. NaoXinTong Inhibits the Development of Diabetic Retinopathy in dbdb Mice. Evidence-Based Complementary and Alternative Medicine،Vol. 2015, no. 2015, pp.1-8.
https://search.emarefa.net/detail/BIM-1061270
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Liu, Mengyang…[et al.]. NaoXinTong Inhibits the Development of Diabetic Retinopathy in dbdb Mice. Evidence-Based Complementary and Alternative Medicine No. 2015 (2015), pp.1-8.
https://search.emarefa.net/detail/BIM-1061270
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Liu, Mengyang& Pan, Quan& Chen, Yuanli& Yang, Xiaoxiao& Zhao, Buchang& Jia, Lifu…[et al.]. NaoXinTong Inhibits the Development of Diabetic Retinopathy in dbdb Mice. Evidence-Based Complementary and Alternative Medicine. 2015. Vol. 2015, no. 2015, pp.1-8.
https://search.emarefa.net/detail/BIM-1061270
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1061270
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
![](/images/ebook-kashef.png)
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر
![](/images/kashef-image.png)