NaoXinTong Inhibits the Development of Diabetic Retinopathy in dbdb Mice
Joint Authors
Liu, Mengyang
Pan, Quan
Chen, Yuanli
Yang, Xiaoxiao
Zhao, Buchang
Jia, Lifu
Zhu, Yan
Han, Jihong
Li, Xiaoju
Duan, Yajun
Source
Evidence-Based Complementary and Alternative Medicine
Issue
Vol. 2015, Issue 2015 (31 Dec. 2015), pp.1-8, 8 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2015-03-03
Country of Publication
Egypt
No. of Pages
8
Main Subjects
Abstract EN
Buchang NaoXinTong capsule (NXT) is a Chinese Materia Medica standardized product extracted from 16 Chinese traditional medical herbs and widely used for treatment of patients with cerebrovascular and cardiovascular diseases in China.
Formation of microaneurysms plays an important role in the development of diabetic retinopathy.
In this study, we investigated if NXT can protect diabetic mice against the development of diabetic retinopathy.
The db/db mice (~6 weeks old), a diabetic animal model, were divided into two groups and fed normal chow or plus NXT for 14 weeks.
During the treatment, fasting blood glucose levels were monthly determined.
After treatment, retinas were collected to determine retinal thickness, accumulation of carbohydrate macromolecules, and caspase-3 (CAS-3) expression.
Our results demonstrate that administration of NXT decreased fasting blood glucose levels.
Associated with the decreased glucose levels, NXT blocked the diabetes-induced shrink of multiple layers, such as photoreceptor layer and outer nuclear/plexiform layers, in the retina.
NXT also inhibited the diabetes-induced expression of CAS-3 protein and mRNA, MMP-2/9 and TNFα mRNA, accumulation of carbohydrate macromolecules, and formation of acellular capillaries in the retina.
Taken together, our study shows that NXT can inhibit the development of diabetic retinopathy and suggests a new potential application of NXT in clinic.
American Psychological Association (APA)
Liu, Mengyang& Pan, Quan& Chen, Yuanli& Yang, Xiaoxiao& Zhao, Buchang& Jia, Lifu…[et al.]. 2015. NaoXinTong Inhibits the Development of Diabetic Retinopathy in dbdb Mice. Evidence-Based Complementary and Alternative Medicine،Vol. 2015, no. 2015, pp.1-8.
https://search.emarefa.net/detail/BIM-1061270
Modern Language Association (MLA)
Liu, Mengyang…[et al.]. NaoXinTong Inhibits the Development of Diabetic Retinopathy in dbdb Mice. Evidence-Based Complementary and Alternative Medicine No. 2015 (2015), pp.1-8.
https://search.emarefa.net/detail/BIM-1061270
American Medical Association (AMA)
Liu, Mengyang& Pan, Quan& Chen, Yuanli& Yang, Xiaoxiao& Zhao, Buchang& Jia, Lifu…[et al.]. NaoXinTong Inhibits the Development of Diabetic Retinopathy in dbdb Mice. Evidence-Based Complementary and Alternative Medicine. 2015. Vol. 2015, no. 2015, pp.1-8.
https://search.emarefa.net/detail/BIM-1061270
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1061270