A Standardized Traditional Chinese Medicine Preparation Named Yejuhua Capsule Ameliorates Lipopolysaccharide-Induced Acute Lung Injury in Mice via Downregulating Toll-Like Receptor 4Nuclear Factor-κB
المؤلفون المشاركون
Su, Zuqing
Su, Zi-Ren
Zhao, Xiao-Ning
Chen, Zhi-Wei
Li, Yu-Cui
Li, Chu-Wen
Lai, Xiao-Ping
Wu, Xiao-Li
المصدر
Evidence-Based Complementary and Alternative Medicine
العدد
المجلد 2015، العدد 2015 (31 ديسمبر/كانون الأول 2015)، ص ص. 1-15، 15ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2015-03-23
دولة النشر
مصر
عدد الصفحات
15
التخصصات الرئيسية
الملخص EN
A standardized traditional Chinese medicine preparation named Yejuhua capsule (YJH) has been clinically used in treatments of various acute respiratory system diseases with high efficacy and low toxicity.
In this study, we were aiming to evaluate potential effects and to elucidate underlying mechanisms of YJH against lipopolysaccharide- (LPS-) induced acute lung injury (ALI) in mice.
Moreover, the chemical analysis and chromatographic fingerprint study were performed for quality evaluation and control of this drug.
ALI was induced by intratracheal instillation of LPS (5 mg/kg) into the lung in mice and dexamethasone (5 mg/kg, p.o.) was used as a positive control drug.
Results demonstrated that pretreatments with YJH (85, 170, and 340 mg/kg, p.o.) effectively abated LPS-induced histopathologic changes, attenuated the vascular permeability enhancement and edema, inhibited inflammatory cells migrations and protein leakages, suppressed the ability of myeloperoxidase, declined proinflammatory cytokines productions, and downregulated activations of nuclear factor-κB (NF-κB) and expressions of toll-like receptor 4 (TLR4).
This study demonstrated that YJH exerted potential protective effects against LPS-induced ALI in mice and supported that YJH was a potential therapeutic drug for ALI in clinic.
And its mechanisms were at least partially associated with downregulations of TLR4/NF-κB pathways.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Li, Chu-Wen& Chen, Zhi-Wei& Wu, Xiao-Li& Zhao, Xiao-Ning& Su, Zuqing& Li, Yu-Cui…[et al.]. 2015. A Standardized Traditional Chinese Medicine Preparation Named Yejuhua Capsule Ameliorates Lipopolysaccharide-Induced Acute Lung Injury in Mice via Downregulating Toll-Like Receptor 4Nuclear Factor-κB. Evidence-Based Complementary and Alternative Medicine،Vol. 2015, no. 2015, pp.1-15.
https://search.emarefa.net/detail/BIM-1061289
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Li, Chu-Wen…[et al.]. A Standardized Traditional Chinese Medicine Preparation Named Yejuhua Capsule Ameliorates Lipopolysaccharide-Induced Acute Lung Injury in Mice via Downregulating Toll-Like Receptor 4Nuclear Factor-κB. Evidence-Based Complementary and Alternative Medicine No. 2015 (2015), pp.1-15.
https://search.emarefa.net/detail/BIM-1061289
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Li, Chu-Wen& Chen, Zhi-Wei& Wu, Xiao-Li& Zhao, Xiao-Ning& Su, Zuqing& Li, Yu-Cui…[et al.]. A Standardized Traditional Chinese Medicine Preparation Named Yejuhua Capsule Ameliorates Lipopolysaccharide-Induced Acute Lung Injury in Mice via Downregulating Toll-Like Receptor 4Nuclear Factor-κB. Evidence-Based Complementary and Alternative Medicine. 2015. Vol. 2015, no. 2015, pp.1-15.
https://search.emarefa.net/detail/BIM-1061289
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1061289
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر