A Standardized Traditional Chinese Medicine Preparation Named Yejuhua Capsule Ameliorates Lipopolysaccharide-Induced Acute Lung Injury in Mice via Downregulating Toll-Like Receptor 4Nuclear Factor-κB
Joint Authors
Su, Zuqing
Su, Zi-Ren
Zhao, Xiao-Ning
Chen, Zhi-Wei
Li, Yu-Cui
Li, Chu-Wen
Lai, Xiao-Ping
Wu, Xiao-Li
Source
Evidence-Based Complementary and Alternative Medicine
Issue
Vol. 2015, Issue 2015 (31 Dec. 2015), pp.1-15, 15 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2015-03-23
Country of Publication
Egypt
No. of Pages
15
Main Subjects
Abstract EN
A standardized traditional Chinese medicine preparation named Yejuhua capsule (YJH) has been clinically used in treatments of various acute respiratory system diseases with high efficacy and low toxicity.
In this study, we were aiming to evaluate potential effects and to elucidate underlying mechanisms of YJH against lipopolysaccharide- (LPS-) induced acute lung injury (ALI) in mice.
Moreover, the chemical analysis and chromatographic fingerprint study were performed for quality evaluation and control of this drug.
ALI was induced by intratracheal instillation of LPS (5 mg/kg) into the lung in mice and dexamethasone (5 mg/kg, p.o.) was used as a positive control drug.
Results demonstrated that pretreatments with YJH (85, 170, and 340 mg/kg, p.o.) effectively abated LPS-induced histopathologic changes, attenuated the vascular permeability enhancement and edema, inhibited inflammatory cells migrations and protein leakages, suppressed the ability of myeloperoxidase, declined proinflammatory cytokines productions, and downregulated activations of nuclear factor-κB (NF-κB) and expressions of toll-like receptor 4 (TLR4).
This study demonstrated that YJH exerted potential protective effects against LPS-induced ALI in mice and supported that YJH was a potential therapeutic drug for ALI in clinic.
And its mechanisms were at least partially associated with downregulations of TLR4/NF-κB pathways.
American Psychological Association (APA)
Li, Chu-Wen& Chen, Zhi-Wei& Wu, Xiao-Li& Zhao, Xiao-Ning& Su, Zuqing& Li, Yu-Cui…[et al.]. 2015. A Standardized Traditional Chinese Medicine Preparation Named Yejuhua Capsule Ameliorates Lipopolysaccharide-Induced Acute Lung Injury in Mice via Downregulating Toll-Like Receptor 4Nuclear Factor-κB. Evidence-Based Complementary and Alternative Medicine،Vol. 2015, no. 2015, pp.1-15.
https://search.emarefa.net/detail/BIM-1061289
Modern Language Association (MLA)
Li, Chu-Wen…[et al.]. A Standardized Traditional Chinese Medicine Preparation Named Yejuhua Capsule Ameliorates Lipopolysaccharide-Induced Acute Lung Injury in Mice via Downregulating Toll-Like Receptor 4Nuclear Factor-κB. Evidence-Based Complementary and Alternative Medicine No. 2015 (2015), pp.1-15.
https://search.emarefa.net/detail/BIM-1061289
American Medical Association (AMA)
Li, Chu-Wen& Chen, Zhi-Wei& Wu, Xiao-Li& Zhao, Xiao-Ning& Su, Zuqing& Li, Yu-Cui…[et al.]. A Standardized Traditional Chinese Medicine Preparation Named Yejuhua Capsule Ameliorates Lipopolysaccharide-Induced Acute Lung Injury in Mice via Downregulating Toll-Like Receptor 4Nuclear Factor-κB. Evidence-Based Complementary and Alternative Medicine. 2015. Vol. 2015, no. 2015, pp.1-15.
https://search.emarefa.net/detail/BIM-1061289
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1061289