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Anti-Inflammatory Activity of Triterpenes Isolated from Protium paniculatum Oil-Resins
المؤلفون المشاركون
de Almeida, Patrícia D. O.
Boleti, Ana Paula de A.
Rüdiger, André Luis
da Veiga Junior, Valdir Florêncio
Lima, Emerson S.
Lourenço, Geane Antiques
المصدر
Evidence-Based Complementary and Alternative Medicine
العدد
المجلد 2015، العدد 2015 (31 ديسمبر/كانون الأول 2015)، ص ص. 1-10، 10ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2015-12-27
دولة النشر
مصر
عدد الصفحات
10
التخصصات الرئيسية
الملخص EN
Protium is the main genus of the Burseraceae family and one of the most common genera in South America, with an important species called “breu.” Gum and oil-resins of this species are used as tonic and stimulant and for the treatment of ulcers and inflammation.
The present study aims to isolate and investigate the anti-inflammatory activity of triterpene compounds isolated from oil-resin of Protium paniculatum.
The pentacyclic triterpenes α,β-amyrin, acetylated α,β-amyrin, α,β-amyrone, and brein/maniladiol did not alter the viability of murine J774 macrophages (IC50 > 20 µg/mL), with the exception of mixture of brein/maniladiol which showed moderate cytotoxic activity.
Also it was observed that compounds at 10 µg/mL inhibited more than 80% of production of NO•, although only α,β-amyrin was able to inhibit the production of TNF-α ( 52.03 ± 2.4 % ).
The compounds inhibited the production of IL-6 and induced the production of IL-10 in murine J774 macrophages stimulated by LPS.
α,β-Amyrone inhibited the expression of COX-2 and also inhibited the formation of paw or ear edema in rats and mice, having a quick and immediate effect.
This study may provide the basis for future investigations on the therapeutic role of α,β-amyrone in treating inflammation.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
de Almeida, Patrícia D. O.& Boleti, Ana Paula de A.& Rüdiger, André Luis& Lourenço, Geane Antiques& da Veiga Junior, Valdir Florêncio& Lima, Emerson S.. 2015. Anti-Inflammatory Activity of Triterpenes Isolated from Protium paniculatum Oil-Resins. Evidence-Based Complementary and Alternative Medicine،Vol. 2015, no. 2015, pp.1-10.
https://search.emarefa.net/detail/BIM-1061321
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
de Almeida, Patrícia D. O.…[et al.]. Anti-Inflammatory Activity of Triterpenes Isolated from Protium paniculatum Oil-Resins. Evidence-Based Complementary and Alternative Medicine No. 2015 (2015), pp.1-10.
https://search.emarefa.net/detail/BIM-1061321
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
de Almeida, Patrícia D. O.& Boleti, Ana Paula de A.& Rüdiger, André Luis& Lourenço, Geane Antiques& da Veiga Junior, Valdir Florêncio& Lima, Emerson S.. Anti-Inflammatory Activity of Triterpenes Isolated from Protium paniculatum Oil-Resins. Evidence-Based Complementary and Alternative Medicine. 2015. Vol. 2015, no. 2015, pp.1-10.
https://search.emarefa.net/detail/BIM-1061321
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1061321
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
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