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Anti-Inflammatory Activity of Triterpenes Isolated from Protium paniculatum Oil-Resins
Joint Authors
de Almeida, Patrícia D. O.
Boleti, Ana Paula de A.
Rüdiger, André Luis
da Veiga Junior, Valdir Florêncio
Lima, Emerson S.
Lourenço, Geane Antiques
Source
Evidence-Based Complementary and Alternative Medicine
Issue
Vol. 2015, Issue 2015 (31 Dec. 2015), pp.1-10, 10 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2015-12-27
Country of Publication
Egypt
No. of Pages
10
Main Subjects
Abstract EN
Protium is the main genus of the Burseraceae family and one of the most common genera in South America, with an important species called “breu.” Gum and oil-resins of this species are used as tonic and stimulant and for the treatment of ulcers and inflammation.
The present study aims to isolate and investigate the anti-inflammatory activity of triterpene compounds isolated from oil-resin of Protium paniculatum.
The pentacyclic triterpenes α,β-amyrin, acetylated α,β-amyrin, α,β-amyrone, and brein/maniladiol did not alter the viability of murine J774 macrophages (IC50 > 20 µg/mL), with the exception of mixture of brein/maniladiol which showed moderate cytotoxic activity.
Also it was observed that compounds at 10 µg/mL inhibited more than 80% of production of NO•, although only α,β-amyrin was able to inhibit the production of TNF-α ( 52.03 ± 2.4 % ).
The compounds inhibited the production of IL-6 and induced the production of IL-10 in murine J774 macrophages stimulated by LPS.
α,β-Amyrone inhibited the expression of COX-2 and also inhibited the formation of paw or ear edema in rats and mice, having a quick and immediate effect.
This study may provide the basis for future investigations on the therapeutic role of α,β-amyrone in treating inflammation.
American Psychological Association (APA)
de Almeida, Patrícia D. O.& Boleti, Ana Paula de A.& Rüdiger, André Luis& Lourenço, Geane Antiques& da Veiga Junior, Valdir Florêncio& Lima, Emerson S.. 2015. Anti-Inflammatory Activity of Triterpenes Isolated from Protium paniculatum Oil-Resins. Evidence-Based Complementary and Alternative Medicine،Vol. 2015, no. 2015, pp.1-10.
https://search.emarefa.net/detail/BIM-1061321
Modern Language Association (MLA)
de Almeida, Patrícia D. O.…[et al.]. Anti-Inflammatory Activity of Triterpenes Isolated from Protium paniculatum Oil-Resins. Evidence-Based Complementary and Alternative Medicine No. 2015 (2015), pp.1-10.
https://search.emarefa.net/detail/BIM-1061321
American Medical Association (AMA)
de Almeida, Patrícia D. O.& Boleti, Ana Paula de A.& Rüdiger, André Luis& Lourenço, Geane Antiques& da Veiga Junior, Valdir Florêncio& Lima, Emerson S.. Anti-Inflammatory Activity of Triterpenes Isolated from Protium paniculatum Oil-Resins. Evidence-Based Complementary and Alternative Medicine. 2015. Vol. 2015, no. 2015, pp.1-10.
https://search.emarefa.net/detail/BIM-1061321
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1061321