Ethanol Extract of Perilla frutescens Suppresses Allergen-Specific Th2 Responses and Alleviates Airway Inflammation and Hyperreactivity in Ovalbumin-Sensitized Murine Model of Asthma
المؤلفون المشاركون
Chen, Miaw-Ling
Wu, Chi-Heng
Hung, Li-Shiuan
Lin, Bi-Fong
المصدر
Evidence-Based Complementary and Alternative Medicine
العدد
المجلد 2015، العدد 2015 (31 ديسمبر/كانون الأول 2015)، ص ص. 1-8، 8ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2015-04-20
دولة النشر
مصر
عدد الصفحات
8
التخصصات الرئيسية
الملخص EN
This study was to investigate the effects of different fractions of Perilla frutescens (Pf)leaves extracted by water or ethanol on asthma.
BALB/c mice sensitized intraperitoneally andchallenged with ovalbumin (OVA) were divided into six groups.
Each group of mice wastube-feeding with 0 (control), 80 μg (PfWL), or 320 μg (PfWH) water extracts or 80 μg(PfEL) or 320 μg (PfEH) ethanol extracts of perilla leaves daily for 3 weeks.
A negativecontrol group (PBS) was neither sensitized nor treated with Pf.
The effects of perilla leaveextracts on allergic immune response were evaluated.
The results showed that OVA-specificIL-5 and IL-13 secretions from OVA-stimulated splenocytes were significantly suppressed inthe ethanol extract groups PfEL and PfEH.
Serum level of anti-OVA IgE tended to be lower inthe PfEH group.
The inflammatory mediators, such as eotaxin and histamine, and total cells,particularly eosinophils in bronchoalveolar lavage fluid (BALF), were also decreased in thePfEL and the PfEH groups.
Therefore, the PfEL and the PfEH groups had significantly lowermethacholine-induced hyperresponsiveness (AHR).
In conclusion, ethanol extracts, rather thanwater extract, of perilla leaves could significantly suppress Th2 responses and airwayinflammation in allergic murine model of asthma.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Chen, Miaw-Ling& Wu, Chi-Heng& Hung, Li-Shiuan& Lin, Bi-Fong. 2015. Ethanol Extract of Perilla frutescens Suppresses Allergen-Specific Th2 Responses and Alleviates Airway Inflammation and Hyperreactivity in Ovalbumin-Sensitized Murine Model of Asthma. Evidence-Based Complementary and Alternative Medicine،Vol. 2015, no. 2015, pp.1-8.
https://search.emarefa.net/detail/BIM-1061356
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Chen, Miaw-Ling…[et al.]. Ethanol Extract of Perilla frutescens Suppresses Allergen-Specific Th2 Responses and Alleviates Airway Inflammation and Hyperreactivity in Ovalbumin-Sensitized Murine Model of Asthma. Evidence-Based Complementary and Alternative Medicine No. 2015 (2015), pp.1-8.
https://search.emarefa.net/detail/BIM-1061356
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Chen, Miaw-Ling& Wu, Chi-Heng& Hung, Li-Shiuan& Lin, Bi-Fong. Ethanol Extract of Perilla frutescens Suppresses Allergen-Specific Th2 Responses and Alleviates Airway Inflammation and Hyperreactivity in Ovalbumin-Sensitized Murine Model of Asthma. Evidence-Based Complementary and Alternative Medicine. 2015. Vol. 2015, no. 2015, pp.1-8.
https://search.emarefa.net/detail/BIM-1061356
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1061356
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر