Ethanol Extract of Perilla frutescens Suppresses Allergen-Specific Th2 Responses and Alleviates Airway Inflammation and Hyperreactivity in Ovalbumin-Sensitized Murine Model of Asthma
Joint Authors
Chen, Miaw-Ling
Wu, Chi-Heng
Hung, Li-Shiuan
Lin, Bi-Fong
Source
Evidence-Based Complementary and Alternative Medicine
Issue
Vol. 2015, Issue 2015 (31 Dec. 2015), pp.1-8, 8 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2015-04-20
Country of Publication
Egypt
No. of Pages
8
Main Subjects
Abstract EN
This study was to investigate the effects of different fractions of Perilla frutescens (Pf)leaves extracted by water or ethanol on asthma.
BALB/c mice sensitized intraperitoneally andchallenged with ovalbumin (OVA) were divided into six groups.
Each group of mice wastube-feeding with 0 (control), 80 μg (PfWL), or 320 μg (PfWH) water extracts or 80 μg(PfEL) or 320 μg (PfEH) ethanol extracts of perilla leaves daily for 3 weeks.
A negativecontrol group (PBS) was neither sensitized nor treated with Pf.
The effects of perilla leaveextracts on allergic immune response were evaluated.
The results showed that OVA-specificIL-5 and IL-13 secretions from OVA-stimulated splenocytes were significantly suppressed inthe ethanol extract groups PfEL and PfEH.
Serum level of anti-OVA IgE tended to be lower inthe PfEH group.
The inflammatory mediators, such as eotaxin and histamine, and total cells,particularly eosinophils in bronchoalveolar lavage fluid (BALF), were also decreased in thePfEL and the PfEH groups.
Therefore, the PfEL and the PfEH groups had significantly lowermethacholine-induced hyperresponsiveness (AHR).
In conclusion, ethanol extracts, rather thanwater extract, of perilla leaves could significantly suppress Th2 responses and airwayinflammation in allergic murine model of asthma.
American Psychological Association (APA)
Chen, Miaw-Ling& Wu, Chi-Heng& Hung, Li-Shiuan& Lin, Bi-Fong. 2015. Ethanol Extract of Perilla frutescens Suppresses Allergen-Specific Th2 Responses and Alleviates Airway Inflammation and Hyperreactivity in Ovalbumin-Sensitized Murine Model of Asthma. Evidence-Based Complementary and Alternative Medicine،Vol. 2015, no. 2015, pp.1-8.
https://search.emarefa.net/detail/BIM-1061356
Modern Language Association (MLA)
Chen, Miaw-Ling…[et al.]. Ethanol Extract of Perilla frutescens Suppresses Allergen-Specific Th2 Responses and Alleviates Airway Inflammation and Hyperreactivity in Ovalbumin-Sensitized Murine Model of Asthma. Evidence-Based Complementary and Alternative Medicine No. 2015 (2015), pp.1-8.
https://search.emarefa.net/detail/BIM-1061356
American Medical Association (AMA)
Chen, Miaw-Ling& Wu, Chi-Heng& Hung, Li-Shiuan& Lin, Bi-Fong. Ethanol Extract of Perilla frutescens Suppresses Allergen-Specific Th2 Responses and Alleviates Airway Inflammation and Hyperreactivity in Ovalbumin-Sensitized Murine Model of Asthma. Evidence-Based Complementary and Alternative Medicine. 2015. Vol. 2015, no. 2015, pp.1-8.
https://search.emarefa.net/detail/BIM-1061356
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1061356