Anti-Inflammatory Property of Plantago major Leaf Extract Reduces the Inflammatory Reaction in Experimental Acetaminophen-Induced Liver Injury
المؤلفون المشاركون
Hussan, Farida
Othman, Faizah
Budin, Siti Balkis
Mansor, Adila Sofea
Hassan, Siti Nazihahasma
Tengku Nor Effendy Kamaruddin, Tg. Nurul Tasnim
المصدر
Evidence-Based Complementary and Alternative Medicine
العدد
المجلد 2015، العدد 2015 (31 ديسمبر/كانون الأول 2015)، ص ص. 1-7، 7ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2015-08-02
دولة النشر
مصر
عدد الصفحات
7
التخصصات الرئيسية
الملخص EN
Hepatic injury induces inflammatory process and cell necrosis.
Plantago major is traditionally used for various diseases.
This study aimed to determine the anti-inflammatory property of P.
major leaf extracts on inflammatory reaction following acetaminophen (APAP) hepatotoxicity.
Thirty male Sprague-Dawley rats were divided into 5 groups, namely, normal control (C), APAP, aqueous (APAP + AQ), methanol (APAP + MT), and ethanol (APAP + ET) extract treated groups.
All APAP groups received oral APAP (2 g/kg) at day 0.
Then, 1000 mg/kg dose of P.
major extracts was given for six days.
The levels of liver transaminases were measured at day 1 and day 7 after APAP induction.
At day 7, the blood and liver tissue were collected to determine plasma cytokines and tissue 11β-HSD type 1 enzyme.
The in vitro anti-inflammatory activities of methanol, ethanol, and aqueous extracts were 26.74 ± 1.6%, 21.69 ± 2.81%, and 12.23 ± 3.15%, respectively.
The ALT and AST levels were significantly higher in the APAP groups at day 1 whereas the enzyme levels of all groups showed no significant difference at day 7.
The extracts treatment significantly reduced the proinflammatory cytokine levels and significantly increased the 11β-HSD type 1 enzyme activity (p<0.05).
In conclusion, the P.
major extracts attenuate the inflammatory reaction following APAP-induced liver injury.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Hussan, Farida& Mansor, Adila Sofea& Hassan, Siti Nazihahasma& Tengku Nor Effendy Kamaruddin, Tg. Nurul Tasnim& Budin, Siti Balkis& Othman, Faizah. 2015. Anti-Inflammatory Property of Plantago major Leaf Extract Reduces the Inflammatory Reaction in Experimental Acetaminophen-Induced Liver Injury. Evidence-Based Complementary and Alternative Medicine،Vol. 2015, no. 2015, pp.1-7.
https://search.emarefa.net/detail/BIM-1061374
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Hussan, Farida…[et al.]. Anti-Inflammatory Property of Plantago major Leaf Extract Reduces the Inflammatory Reaction in Experimental Acetaminophen-Induced Liver Injury. Evidence-Based Complementary and Alternative Medicine No. 2015 (2015), pp.1-7.
https://search.emarefa.net/detail/BIM-1061374
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Hussan, Farida& Mansor, Adila Sofea& Hassan, Siti Nazihahasma& Tengku Nor Effendy Kamaruddin, Tg. Nurul Tasnim& Budin, Siti Balkis& Othman, Faizah. Anti-Inflammatory Property of Plantago major Leaf Extract Reduces the Inflammatory Reaction in Experimental Acetaminophen-Induced Liver Injury. Evidence-Based Complementary and Alternative Medicine. 2015. Vol. 2015, no. 2015, pp.1-7.
https://search.emarefa.net/detail/BIM-1061374
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1061374
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر