Luoyutong Treatment Promotes Functional Recovery and Neuronal Plasticity after Cerebral Ischemia-Reperfusion Injury in Rats
المؤلفون المشاركون
Wang, Ning-qun
Wang, Li-ye
Liu, Ping
Wang, Rong-liang
Song, Jue-xian
Gao, Li
Ji, Xun-ming
Luo, Yu-min
Zhao, Hai-Ping
المصدر
Evidence-Based Complementary and Alternative Medicine
العدد
المجلد 2015، العدد 2015 (31 ديسمبر/كانون الأول 2015)، ص ص. 1-12، 12ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2015-12-01
دولة النشر
مصر
عدد الصفحات
12
التخصصات الرئيسية
الملخص EN
Luoyutong (LYT) capsule has been used to treat cerebrovascular diseases clinically in China and is now patented and approved by the State Food and Drug Administration.
In this retrospective validation study we investigated the ability of LYT to protect against cerebral ischemia-reperfusion injury in rats.
Cerebral ischemia-reperfusion injury was induced by middle cerebral artery occlusion followed by reperfusion.
Capsule containing LYT (high dose and medium dose) as treatment group and Citicoline Sodium as positive control treatment group were administered daily to rats 30 min after reperfusion.
Treatment was continued for either 3 days or 14 days.
A saline solution was administered to control animals.
Behavior tests were performed after 3 and 14 days of treatment.
Our findings revealed that LYT treatment improved the neurological outcome, decreased cerebral infarction volume, and reduced apoptosis.
Additionally, LYT improved neural plasticity, as the expression of synaptophysin, microtubule associated protein, and myelin basic protein was upregulated by LYT treatment, while neurofilament 200 expression was reduced.
Moreover, levels of brain derived neurotrophic factor and basic fibroblast growth factor were increased.
Our results suggest that LYT treatment may protect against ischemic injury and improve neural plasticity.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Wang, Ning-qun& Wang, Li-ye& Zhao, Hai-Ping& Liu, Ping& Wang, Rong-liang& Song, Jue-xian…[et al.]. 2015. Luoyutong Treatment Promotes Functional Recovery and Neuronal Plasticity after Cerebral Ischemia-Reperfusion Injury in Rats. Evidence-Based Complementary and Alternative Medicine،Vol. 2015, no. 2015, pp.1-12.
https://search.emarefa.net/detail/BIM-1061419
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Wang, Ning-qun…[et al.]. Luoyutong Treatment Promotes Functional Recovery and Neuronal Plasticity after Cerebral Ischemia-Reperfusion Injury in Rats. Evidence-Based Complementary and Alternative Medicine No. 2015 (2015), pp.1-12.
https://search.emarefa.net/detail/BIM-1061419
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Wang, Ning-qun& Wang, Li-ye& Zhao, Hai-Ping& Liu, Ping& Wang, Rong-liang& Song, Jue-xian…[et al.]. Luoyutong Treatment Promotes Functional Recovery and Neuronal Plasticity after Cerebral Ischemia-Reperfusion Injury in Rats. Evidence-Based Complementary and Alternative Medicine. 2015. Vol. 2015, no. 2015, pp.1-12.
https://search.emarefa.net/detail/BIM-1061419
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1061419
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر