Luoyutong Treatment Promotes Functional Recovery and Neuronal Plasticity after Cerebral Ischemia-Reperfusion Injury in Rats
Joint Authors
Wang, Ning-qun
Wang, Li-ye
Liu, Ping
Wang, Rong-liang
Song, Jue-xian
Gao, Li
Ji, Xun-ming
Luo, Yu-min
Zhao, Hai-Ping
Source
Evidence-Based Complementary and Alternative Medicine
Issue
Vol. 2015, Issue 2015 (31 Dec. 2015), pp.1-12, 12 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2015-12-01
Country of Publication
Egypt
No. of Pages
12
Main Subjects
Abstract EN
Luoyutong (LYT) capsule has been used to treat cerebrovascular diseases clinically in China and is now patented and approved by the State Food and Drug Administration.
In this retrospective validation study we investigated the ability of LYT to protect against cerebral ischemia-reperfusion injury in rats.
Cerebral ischemia-reperfusion injury was induced by middle cerebral artery occlusion followed by reperfusion.
Capsule containing LYT (high dose and medium dose) as treatment group and Citicoline Sodium as positive control treatment group were administered daily to rats 30 min after reperfusion.
Treatment was continued for either 3 days or 14 days.
A saline solution was administered to control animals.
Behavior tests were performed after 3 and 14 days of treatment.
Our findings revealed that LYT treatment improved the neurological outcome, decreased cerebral infarction volume, and reduced apoptosis.
Additionally, LYT improved neural plasticity, as the expression of synaptophysin, microtubule associated protein, and myelin basic protein was upregulated by LYT treatment, while neurofilament 200 expression was reduced.
Moreover, levels of brain derived neurotrophic factor and basic fibroblast growth factor were increased.
Our results suggest that LYT treatment may protect against ischemic injury and improve neural plasticity.
American Psychological Association (APA)
Wang, Ning-qun& Wang, Li-ye& Zhao, Hai-Ping& Liu, Ping& Wang, Rong-liang& Song, Jue-xian…[et al.]. 2015. Luoyutong Treatment Promotes Functional Recovery and Neuronal Plasticity after Cerebral Ischemia-Reperfusion Injury in Rats. Evidence-Based Complementary and Alternative Medicine،Vol. 2015, no. 2015, pp.1-12.
https://search.emarefa.net/detail/BIM-1061419
Modern Language Association (MLA)
Wang, Ning-qun…[et al.]. Luoyutong Treatment Promotes Functional Recovery and Neuronal Plasticity after Cerebral Ischemia-Reperfusion Injury in Rats. Evidence-Based Complementary and Alternative Medicine No. 2015 (2015), pp.1-12.
https://search.emarefa.net/detail/BIM-1061419
American Medical Association (AMA)
Wang, Ning-qun& Wang, Li-ye& Zhao, Hai-Ping& Liu, Ping& Wang, Rong-liang& Song, Jue-xian…[et al.]. Luoyutong Treatment Promotes Functional Recovery and Neuronal Plasticity after Cerebral Ischemia-Reperfusion Injury in Rats. Evidence-Based Complementary and Alternative Medicine. 2015. Vol. 2015, no. 2015, pp.1-12.
https://search.emarefa.net/detail/BIM-1061419
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1061419