In Vitro Antileukemic Activity of Xanthosoma sagittifolium (Taioba) Leaf Extract
المؤلفون المشاركون
Caxito, Marina L. C.
Correia, Rachell R.
Gomes, Anne Caroline C.
Justo, Graça
Coelho, Marsen G. P.
Sakuragui, Cássia M.
Kuster, Ricardo M.
Sabino, Katia C. C.
المصدر
Evidence-Based Complementary and Alternative Medicine
العدد
المجلد 2015، العدد 2015 (31 ديسمبر/كانون الأول 2015)، ص ص. 1-10، 10ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2015-06-09
دولة النشر
مصر
عدد الصفحات
10
التخصصات الرئيسية
الملخص EN
Xanthosoma sagittifolium Schott is a herb of the Araceae family, popularly known as taioba, which is consumed as food in some regions of Brazil, Africa, and Asia.
This species has already been evaluated for the antifungal activities.
However, based on its potential antitumor activity, the present study further aimed to examine the antitumor, as well as chelation, activity of X.
sagittifolium leaf extract.
Results showed that hydroethanolic extract of X.
sagittifolium leaves (HEXs-L) exhibits cytotoxic effects against the immortalized line of human T-lymphocytic (Jurkat) and myelogenous (K562) leukemia cells, but not nontumor RAW 264.7 macrophages or NIH/3T3 fibroblasts.
HEXs-L inhibited 50.3% of Jurkat cell proliferation, reducing by 20% cells in G2/M phase, but increasing cells in sub-G1 phase, thereby inducing apoptosis by 54%.
In addition, HEXs-L inhibited NO production by 59%, as determined by Griess reaction, and chelated 93.8% of free Fe(II), as demonstrated by ferrozine assay.
Phytochemical studies were carried out by ESI-MS, identifying apigenin di-C-glycosides as major compounds.
Overall, this work revealed that leaf extract of Xanthosoma sagittifolium presented chelating activity and in vitro antitumor activity, arresting cell cycle and inducing apoptosis of leukemia cells, thus providing evidence that taioba leaves may have practical application in cancer therapy.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Caxito, Marina L. C.& Correia, Rachell R.& Gomes, Anne Caroline C.& Justo, Graça& Coelho, Marsen G. P.& Sakuragui, Cássia M.…[et al.]. 2015. In Vitro Antileukemic Activity of Xanthosoma sagittifolium (Taioba) Leaf Extract. Evidence-Based Complementary and Alternative Medicine،Vol. 2015, no. 2015, pp.1-10.
https://search.emarefa.net/detail/BIM-1061434
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Caxito, Marina L. C.…[et al.]. In Vitro Antileukemic Activity of Xanthosoma sagittifolium (Taioba) Leaf Extract. Evidence-Based Complementary and Alternative Medicine No. 2015 (2015), pp.1-10.
https://search.emarefa.net/detail/BIM-1061434
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Caxito, Marina L. C.& Correia, Rachell R.& Gomes, Anne Caroline C.& Justo, Graça& Coelho, Marsen G. P.& Sakuragui, Cássia M.…[et al.]. In Vitro Antileukemic Activity of Xanthosoma sagittifolium (Taioba) Leaf Extract. Evidence-Based Complementary and Alternative Medicine. 2015. Vol. 2015, no. 2015, pp.1-10.
https://search.emarefa.net/detail/BIM-1061434
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1061434
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر