In Vitro Antileukemic Activity of Xanthosoma sagittifolium (Taioba) Leaf Extract
Joint Authors
Caxito, Marina L. C.
Correia, Rachell R.
Gomes, Anne Caroline C.
Justo, Graça
Coelho, Marsen G. P.
Sakuragui, Cássia M.
Kuster, Ricardo M.
Sabino, Katia C. C.
Source
Evidence-Based Complementary and Alternative Medicine
Issue
Vol. 2015, Issue 2015 (31 Dec. 2015), pp.1-10, 10 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2015-06-09
Country of Publication
Egypt
No. of Pages
10
Main Subjects
Abstract EN
Xanthosoma sagittifolium Schott is a herb of the Araceae family, popularly known as taioba, which is consumed as food in some regions of Brazil, Africa, and Asia.
This species has already been evaluated for the antifungal activities.
However, based on its potential antitumor activity, the present study further aimed to examine the antitumor, as well as chelation, activity of X.
sagittifolium leaf extract.
Results showed that hydroethanolic extract of X.
sagittifolium leaves (HEXs-L) exhibits cytotoxic effects against the immortalized line of human T-lymphocytic (Jurkat) and myelogenous (K562) leukemia cells, but not nontumor RAW 264.7 macrophages or NIH/3T3 fibroblasts.
HEXs-L inhibited 50.3% of Jurkat cell proliferation, reducing by 20% cells in G2/M phase, but increasing cells in sub-G1 phase, thereby inducing apoptosis by 54%.
In addition, HEXs-L inhibited NO production by 59%, as determined by Griess reaction, and chelated 93.8% of free Fe(II), as demonstrated by ferrozine assay.
Phytochemical studies were carried out by ESI-MS, identifying apigenin di-C-glycosides as major compounds.
Overall, this work revealed that leaf extract of Xanthosoma sagittifolium presented chelating activity and in vitro antitumor activity, arresting cell cycle and inducing apoptosis of leukemia cells, thus providing evidence that taioba leaves may have practical application in cancer therapy.
American Psychological Association (APA)
Caxito, Marina L. C.& Correia, Rachell R.& Gomes, Anne Caroline C.& Justo, Graça& Coelho, Marsen G. P.& Sakuragui, Cássia M.…[et al.]. 2015. In Vitro Antileukemic Activity of Xanthosoma sagittifolium (Taioba) Leaf Extract. Evidence-Based Complementary and Alternative Medicine،Vol. 2015, no. 2015, pp.1-10.
https://search.emarefa.net/detail/BIM-1061434
Modern Language Association (MLA)
Caxito, Marina L. C.…[et al.]. In Vitro Antileukemic Activity of Xanthosoma sagittifolium (Taioba) Leaf Extract. Evidence-Based Complementary and Alternative Medicine No. 2015 (2015), pp.1-10.
https://search.emarefa.net/detail/BIM-1061434
American Medical Association (AMA)
Caxito, Marina L. C.& Correia, Rachell R.& Gomes, Anne Caroline C.& Justo, Graça& Coelho, Marsen G. P.& Sakuragui, Cássia M.…[et al.]. In Vitro Antileukemic Activity of Xanthosoma sagittifolium (Taioba) Leaf Extract. Evidence-Based Complementary and Alternative Medicine. 2015. Vol. 2015, no. 2015, pp.1-10.
https://search.emarefa.net/detail/BIM-1061434
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1061434