Electroacupuncture Stimulates Remodeling of Extracellular Matrix by Inhibiting Apoptosis in a Rabbit Model of Disc Degeneration
المؤلفون المشاركون
Huang, Guo-fu
Zou, Jing
Shi, Jing
Zhang, Dong-you
Zhang, Qi
Gao, Yu
Wang, Bo-yi
Peng, Hong-fen
Zhang, Tang-fa
المصدر
Evidence-Based Complementary and Alternative Medicine
العدد
المجلد 2015، العدد 2015 (31 ديسمبر/كانون الأول 2015)، ص ص. 1-9، 9ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2015-02-11
دولة النشر
مصر
عدد الصفحات
9
التخصصات الرئيسية
الملخص EN
The present study was designed to determine whether EA stimulates remodeling of extracellular matrix by inhibiting apoptosis in degenerated disc.
40 rabbits were randomly assigned to one of the four groups.
Animal model was established by a loading device.
Magnetic resonance imaging and Pfirrmann’s classification were obtained to evaluate both the model and the EA treatment on disc degeneration.
The ultrastructure of discs was observed by TEM.
Apoptosis involvement was determined with TUNEL staining and western blot for the protein expression of Bax and Bcl-2.
The results indicated that EA intervention decreased the MRI grades.
TEM analysis showed an apparent remodeling and rearrangement of disc ECM after EA intervention for 28 days.
The number of TUNEL-positive cells in the EA group was significantly lower than that in the compression group.
The protein expression demonstrated an antiapoptosis effect mediated by EA.
Increased expression of Bcl-2 proteins and reduced Bax protein expression were detected after 28 days treatment.
It was concluded that antiapoptosis pathway probably participates in the mechanism of EA stimulating the remodeling of ECM in disc degeneration.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Huang, Guo-fu& Zou, Jing& Shi, Jing& Zhang, Dong-you& Peng, Hong-fen& Zhang, Qi…[et al.]. 2015. Electroacupuncture Stimulates Remodeling of Extracellular Matrix by Inhibiting Apoptosis in a Rabbit Model of Disc Degeneration. Evidence-Based Complementary and Alternative Medicine،Vol. 2015, no. 2015, pp.1-9.
https://search.emarefa.net/detail/BIM-1061441
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Huang, Guo-fu…[et al.]. Electroacupuncture Stimulates Remodeling of Extracellular Matrix by Inhibiting Apoptosis in a Rabbit Model of Disc Degeneration. Evidence-Based Complementary and Alternative Medicine No. 2015 (2015), pp.1-9.
https://search.emarefa.net/detail/BIM-1061441
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Huang, Guo-fu& Zou, Jing& Shi, Jing& Zhang, Dong-you& Peng, Hong-fen& Zhang, Qi…[et al.]. Electroacupuncture Stimulates Remodeling of Extracellular Matrix by Inhibiting Apoptosis in a Rabbit Model of Disc Degeneration. Evidence-Based Complementary and Alternative Medicine. 2015. Vol. 2015, no. 2015, pp.1-9.
https://search.emarefa.net/detail/BIM-1061441
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1061441
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر