Electroacupuncture Stimulates Remodeling of Extracellular Matrix by Inhibiting Apoptosis in a Rabbit Model of Disc Degeneration
Joint Authors
Huang, Guo-fu
Zou, Jing
Shi, Jing
Zhang, Dong-you
Zhang, Qi
Gao, Yu
Wang, Bo-yi
Peng, Hong-fen
Zhang, Tang-fa
Source
Evidence-Based Complementary and Alternative Medicine
Issue
Vol. 2015, Issue 2015 (31 Dec. 2015), pp.1-9, 9 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2015-02-11
Country of Publication
Egypt
No. of Pages
9
Main Subjects
Abstract EN
The present study was designed to determine whether EA stimulates remodeling of extracellular matrix by inhibiting apoptosis in degenerated disc.
40 rabbits were randomly assigned to one of the four groups.
Animal model was established by a loading device.
Magnetic resonance imaging and Pfirrmann’s classification were obtained to evaluate both the model and the EA treatment on disc degeneration.
The ultrastructure of discs was observed by TEM.
Apoptosis involvement was determined with TUNEL staining and western blot for the protein expression of Bax and Bcl-2.
The results indicated that EA intervention decreased the MRI grades.
TEM analysis showed an apparent remodeling and rearrangement of disc ECM after EA intervention for 28 days.
The number of TUNEL-positive cells in the EA group was significantly lower than that in the compression group.
The protein expression demonstrated an antiapoptosis effect mediated by EA.
Increased expression of Bcl-2 proteins and reduced Bax protein expression were detected after 28 days treatment.
It was concluded that antiapoptosis pathway probably participates in the mechanism of EA stimulating the remodeling of ECM in disc degeneration.
American Psychological Association (APA)
Huang, Guo-fu& Zou, Jing& Shi, Jing& Zhang, Dong-you& Peng, Hong-fen& Zhang, Qi…[et al.]. 2015. Electroacupuncture Stimulates Remodeling of Extracellular Matrix by Inhibiting Apoptosis in a Rabbit Model of Disc Degeneration. Evidence-Based Complementary and Alternative Medicine،Vol. 2015, no. 2015, pp.1-9.
https://search.emarefa.net/detail/BIM-1061441
Modern Language Association (MLA)
Huang, Guo-fu…[et al.]. Electroacupuncture Stimulates Remodeling of Extracellular Matrix by Inhibiting Apoptosis in a Rabbit Model of Disc Degeneration. Evidence-Based Complementary and Alternative Medicine No. 2015 (2015), pp.1-9.
https://search.emarefa.net/detail/BIM-1061441
American Medical Association (AMA)
Huang, Guo-fu& Zou, Jing& Shi, Jing& Zhang, Dong-you& Peng, Hong-fen& Zhang, Qi…[et al.]. Electroacupuncture Stimulates Remodeling of Extracellular Matrix by Inhibiting Apoptosis in a Rabbit Model of Disc Degeneration. Evidence-Based Complementary and Alternative Medicine. 2015. Vol. 2015, no. 2015, pp.1-9.
https://search.emarefa.net/detail/BIM-1061441
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1061441