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Berberine Regulated Lipid Metabolism in the Presence of C75, Compound C, and TOFA in Breast Cancer Cell Line MCF-7
المؤلفون المشاركون
Tan, Wen
Zhong, Zhangfeng
Suo, Zhanwei
Yang, Xian
Hu, Xiaodong
Wang, Yitao
Wang, Shengpeng
المصدر
Evidence-Based Complementary and Alternative Medicine
العدد
المجلد 2015، العدد 2015 (31 ديسمبر/كانون الأول 2015)، ص ص. 1-10، 10ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2015-08-13
دولة النشر
مصر
عدد الصفحات
10
التخصصات الرئيسية
الملخص EN
Berberine interfering with cancer reprogramming metabolism was confirmed in our previous study.
Lipid metabolism and mitochondrial function were also the core parts in reprogramming metabolism.
In the presence of some energy-related inhibitors, including C75, compound C, and TOFA, the discrete roles of berberine in lipid metabolism and mitochondrial function were elucidated.
An altered lipid metabolism induced by berberine was observed under the inhibition of FASN, AMPK, and ACC in breast cancer cell MCF-7.
And the reversion of berberine-induced lipid suppression indicated that ACC inhibition might be involved in that process instead of FASN inhibition.
A robust apoptosis induced by berberine even under the inhibition of AMPK and lipid synthesis was also indicated.
Finally, mitochondrial function regulation under the inhibition of AMPK and ACC might be in an ACL-independent manner.
Undoubtedly, the detailed mechanisms of berberine interfering with lipid metabolism and mitochondrial function combined with energy-related inhibitors need further investigation, including the potential compensatory mechanisms for ATP production and the upregulation of ACL.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Tan, Wen& Zhong, Zhangfeng& Wang, Shengpeng& Suo, Zhanwei& Yang, Xian& Hu, Xiaodong…[et al.]. 2015. Berberine Regulated Lipid Metabolism in the Presence of C75, Compound C, and TOFA in Breast Cancer Cell Line MCF-7. Evidence-Based Complementary and Alternative Medicine،Vol. 2015, no. 2015, pp.1-10.
https://search.emarefa.net/detail/BIM-1061455
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Tan, Wen…[et al.]. Berberine Regulated Lipid Metabolism in the Presence of C75, Compound C, and TOFA in Breast Cancer Cell Line MCF-7. Evidence-Based Complementary and Alternative Medicine No. 2015 (2015), pp.1-10.
https://search.emarefa.net/detail/BIM-1061455
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Tan, Wen& Zhong, Zhangfeng& Wang, Shengpeng& Suo, Zhanwei& Yang, Xian& Hu, Xiaodong…[et al.]. Berberine Regulated Lipid Metabolism in the Presence of C75, Compound C, and TOFA in Breast Cancer Cell Line MCF-7. Evidence-Based Complementary and Alternative Medicine. 2015. Vol. 2015, no. 2015, pp.1-10.
https://search.emarefa.net/detail/BIM-1061455
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1061455
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
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