Berberine Regulated Lipid Metabolism in the Presence of C75, Compound C, and TOFA in Breast Cancer Cell Line MCF-7
Joint Authors
Tan, Wen
Zhong, Zhangfeng
Suo, Zhanwei
Yang, Xian
Hu, Xiaodong
Wang, Yitao
Wang, Shengpeng
Source
Evidence-Based Complementary and Alternative Medicine
Issue
Vol. 2015, Issue 2015 (31 Dec. 2015), pp.1-10, 10 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2015-08-13
Country of Publication
Egypt
No. of Pages
10
Main Subjects
Abstract EN
Berberine interfering with cancer reprogramming metabolism was confirmed in our previous study.
Lipid metabolism and mitochondrial function were also the core parts in reprogramming metabolism.
In the presence of some energy-related inhibitors, including C75, compound C, and TOFA, the discrete roles of berberine in lipid metabolism and mitochondrial function were elucidated.
An altered lipid metabolism induced by berberine was observed under the inhibition of FASN, AMPK, and ACC in breast cancer cell MCF-7.
And the reversion of berberine-induced lipid suppression indicated that ACC inhibition might be involved in that process instead of FASN inhibition.
A robust apoptosis induced by berberine even under the inhibition of AMPK and lipid synthesis was also indicated.
Finally, mitochondrial function regulation under the inhibition of AMPK and ACC might be in an ACL-independent manner.
Undoubtedly, the detailed mechanisms of berberine interfering with lipid metabolism and mitochondrial function combined with energy-related inhibitors need further investigation, including the potential compensatory mechanisms for ATP production and the upregulation of ACL.
American Psychological Association (APA)
Tan, Wen& Zhong, Zhangfeng& Wang, Shengpeng& Suo, Zhanwei& Yang, Xian& Hu, Xiaodong…[et al.]. 2015. Berberine Regulated Lipid Metabolism in the Presence of C75, Compound C, and TOFA in Breast Cancer Cell Line MCF-7. Evidence-Based Complementary and Alternative Medicine،Vol. 2015, no. 2015, pp.1-10.
https://search.emarefa.net/detail/BIM-1061455
Modern Language Association (MLA)
Tan, Wen…[et al.]. Berberine Regulated Lipid Metabolism in the Presence of C75, Compound C, and TOFA in Breast Cancer Cell Line MCF-7. Evidence-Based Complementary and Alternative Medicine No. 2015 (2015), pp.1-10.
https://search.emarefa.net/detail/BIM-1061455
American Medical Association (AMA)
Tan, Wen& Zhong, Zhangfeng& Wang, Shengpeng& Suo, Zhanwei& Yang, Xian& Hu, Xiaodong…[et al.]. Berberine Regulated Lipid Metabolism in the Presence of C75, Compound C, and TOFA in Breast Cancer Cell Line MCF-7. Evidence-Based Complementary and Alternative Medicine. 2015. Vol. 2015, no. 2015, pp.1-10.
https://search.emarefa.net/detail/BIM-1061455
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1061455