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The Stimulative Effect of Yangjing Capsule on Testosterone Synthesis through Nur77 Pathway in Leydig Cells
المؤلفون المشاركون
Gao, Chao
Cui, Yu-Gui
Sun, Dalin
Jin, Baofang
Zhang, Xindong
Gu, Yalong
Zhao, Hongle
Cai, Bin
Gao, Li
Tang, Zhian
المصدر
Evidence-Based Complementary and Alternative Medicine
العدد
المجلد 2015، العدد 2015 (31 ديسمبر/كانون الأول 2015)، ص ص. 1-8، 8ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2015-08-27
دولة النشر
مصر
عدد الصفحات
8
التخصصات الرئيسية
الملخص EN
Yangjing Capsule (YC), an innovative Chinese medicine based on traditional prescription, promotes testosterone synthesis by upregulating the expression of steroidogenic enzymes.
Nur77 as a nuclear receptor is known to regulate the expression of many steroid synthetases.
This study aimed to explore the potential mechanisms by which YC regulates testosterone synthesis in Leydig cells.
Real-time PCR and Western blot analysis were employed to assess the expressions of steroidogenic enzymes and Nur77 after treating MLTC-1 cells with YC.
The luciferase reporter gene assay was performed to detect the activity of Nur77 gene promoter.
Also, the expressions of steroid synthases were detected after Nur77 gene was knocked down.
YC significantly stimulated Nur77 production and upregulated StAR and HSD3B expression, and this agrees with the activity of Nur77 gene promoter that was significantly enhanced by YC.
Interestingly, knockdown of Nur77 blocked the above YC’s effects and consequently inhibited testosterone synthesis in MLTC-1 cells.
YC promotes StAR and HSD3B expression and upregulates testosterone synthesis in Leydig cells, which is mediated by Nur77 pathway.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Gu, Yalong& Zhang, Xindong& Sun, Dalin& Zhao, Hongle& Cai, Bin& Gao, Chao…[et al.]. 2015. The Stimulative Effect of Yangjing Capsule on Testosterone Synthesis through Nur77 Pathway in Leydig Cells. Evidence-Based Complementary and Alternative Medicine،Vol. 2015, no. 2015, pp.1-8.
https://search.emarefa.net/detail/BIM-1061470
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Gu, Yalong…[et al.]. The Stimulative Effect of Yangjing Capsule on Testosterone Synthesis through Nur77 Pathway in Leydig Cells. Evidence-Based Complementary and Alternative Medicine No. 2015 (2015), pp.1-8.
https://search.emarefa.net/detail/BIM-1061470
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Gu, Yalong& Zhang, Xindong& Sun, Dalin& Zhao, Hongle& Cai, Bin& Gao, Chao…[et al.]. The Stimulative Effect of Yangjing Capsule on Testosterone Synthesis through Nur77 Pathway in Leydig Cells. Evidence-Based Complementary and Alternative Medicine. 2015. Vol. 2015, no. 2015, pp.1-8.
https://search.emarefa.net/detail/BIM-1061470
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1061470
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
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