Effect of Electroacupuncture on Cell Apoptosis and ERK Signal Pathway in the Hippocampus of Adult Rats with Cerebral Ischemia-Reperfusion
المؤلفون المشاركون
Wu, Chunxiao
Wang, Jiao
Li, Chun
Zhou, Guoping
Xu, Xiuhong
Zhang, Xin
Lan, Xiao
المصدر
Evidence-Based Complementary and Alternative Medicine
العدد
المجلد 2015، العدد 2015 (31 ديسمبر/كانون الأول 2015)، ص ص. 1-10، 10ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2015-11-08
دولة النشر
مصر
عدد الصفحات
10
التخصصات الرئيسية
الملخص EN
Background.
EA therapy is a traditional therapeutic approach for alleviation of cerebral I/R-induced brain injury.
We investigated the effect of EA on MCAO rat model to examine the mechanism of apoptosis in the rat hippocampus.
Methods.
200 male Sprague-Dawley rats were randomly divided into sham, I/R, EA, ERK inhibitor (PD), and ERK inhibitor+EA (PD+EA) groups.
Each group was subdivided into 5 groups according to different time points.
Locomotor behaviors were evaluated using neurological scales and morphological examination was performed using HE staining.
Apoptosis index of neural cells in local infarcted area was measured by TUNEL and p-ERK expression was detected using immunohistochemistry technique and western blot analysis.
Results.
Neurological deficit scores and neural apoptosis in the EA group were lower than I/R group at the same time points, respectively.
At different time points, p-ERK level was increased in the ischemic hippocampal CA1 in the EA group as compared to I/R group; the increased level was increased most at 1 day, 3 days, and 1 week (p<0.01).
Conclusion.
EA alleviates neurological deficit, reduces apoptosis index, and simultaneously upregulates the expression of p-ERK signal pathway in rats subjected to I/R injury.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Wu, Chunxiao& Wang, Jiao& Li, Chun& Zhou, Guoping& Xu, Xiuhong& Zhang, Xin…[et al.]. 2015. Effect of Electroacupuncture on Cell Apoptosis and ERK Signal Pathway in the Hippocampus of Adult Rats with Cerebral Ischemia-Reperfusion. Evidence-Based Complementary and Alternative Medicine،Vol. 2015, no. 2015, pp.1-10.
https://search.emarefa.net/detail/BIM-1061479
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Wu, Chunxiao…[et al.]. Effect of Electroacupuncture on Cell Apoptosis and ERK Signal Pathway in the Hippocampus of Adult Rats with Cerebral Ischemia-Reperfusion. Evidence-Based Complementary and Alternative Medicine No. 2015 (2015), pp.1-10.
https://search.emarefa.net/detail/BIM-1061479
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Wu, Chunxiao& Wang, Jiao& Li, Chun& Zhou, Guoping& Xu, Xiuhong& Zhang, Xin…[et al.]. Effect of Electroacupuncture on Cell Apoptosis and ERK Signal Pathway in the Hippocampus of Adult Rats with Cerebral Ischemia-Reperfusion. Evidence-Based Complementary and Alternative Medicine. 2015. Vol. 2015, no. 2015, pp.1-10.
https://search.emarefa.net/detail/BIM-1061479
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1061479
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر