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Intravenous Injections of Human Mesenchymal Stromal Cells Modulated the Redox State in a Rat Model of Radiation Myelopathy
المؤلفون المشاركون
Zhang, Jing
Li, Lian-Bing
Qiu, Zhu
Ren, Hong-Bo
Wu, Jia-Yan
Wang, Tao
Bao, Zhong-Hui
Yang, Ji-Fan
Zheng, Ke
Li, Shao-Lin
Wei, Li
You, Hua
المصدر
Evidence-Based Complementary and Alternative Medicine
العدد
المجلد 2015، العدد 2015 (31 ديسمبر/كانون الأول 2015)، ص ص. 1-6، 6ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2015-08-23
دولة النشر
مصر
عدد الصفحات
6
التخصصات الرئيسية
الملخص EN
The main aim of the present study was to assess the antioxidative effects of human umbilical cord-derived mesenchymal stromal cells (UC-MSCs) in a rat model of radiation myelopathy.
UC-MSCs were isolated from Wharton’s jelly (WJ) of umbilical cords.
An irradiated cervical spinal cord rat model (C2-T2 segment) was generated using a 60Co irradiator to deliver 30 Gy of radiation.
UC-MSCs were injected through the tail vein at 90 days, 97 days, 104 days, and 111 days after-irradiation.
Histological damage was examined by cresyl violet/Nissl staining.
The activities of two antioxidant enzymes catalase (CAT) and glutathione peroxidase (GPX) in the spinal cord were measured by the biomedical assay.
In addition, the levels of vascular endothelial growth factor (VEGF) and angiopoietin-2 (Ang-2) in the spinal cord were determined by ELISA methods.
Multiple injections of UC-MSCs through the tail vein ameliorated neuronal damage in the spinal cord, increased the activities of the antioxidant enzymes CAT and GPX, and increased the levels of VEGF and Ang-2 in the spinal cord.
Our results suggest that multiple injections of UC-MSCs via the tail vein in the rat model of radiation myelopathy could significantly improve the antioxidative microenvironment in vivo.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Zhang, Jing& Li, Lian-Bing& Qiu, Zhu& Ren, Hong-Bo& Wu, Jia-Yan& Wang, Tao…[et al.]. 2015. Intravenous Injections of Human Mesenchymal Stromal Cells Modulated the Redox State in a Rat Model of Radiation Myelopathy. Evidence-Based Complementary and Alternative Medicine،Vol. 2015, no. 2015, pp.1-6.
https://search.emarefa.net/detail/BIM-1061499
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Zhang, Jing…[et al.]. Intravenous Injections of Human Mesenchymal Stromal Cells Modulated the Redox State in a Rat Model of Radiation Myelopathy. Evidence-Based Complementary and Alternative Medicine No. 2015 (2015), pp.1-6.
https://search.emarefa.net/detail/BIM-1061499
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Zhang, Jing& Li, Lian-Bing& Qiu, Zhu& Ren, Hong-Bo& Wu, Jia-Yan& Wang, Tao…[et al.]. Intravenous Injections of Human Mesenchymal Stromal Cells Modulated the Redox State in a Rat Model of Radiation Myelopathy. Evidence-Based Complementary and Alternative Medicine. 2015. Vol. 2015, no. 2015, pp.1-6.
https://search.emarefa.net/detail/BIM-1061499
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1061499
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
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