Intravenous Injections of Human Mesenchymal Stromal Cells Modulated the Redox State in a Rat Model of Radiation Myelopathy
Joint Authors
Zhang, Jing
Li, Lian-Bing
Qiu, Zhu
Ren, Hong-Bo
Wu, Jia-Yan
Wang, Tao
Bao, Zhong-Hui
Yang, Ji-Fan
Zheng, Ke
Li, Shao-Lin
Wei, Li
You, Hua
Source
Evidence-Based Complementary and Alternative Medicine
Issue
Vol. 2015, Issue 2015 (31 Dec. 2015), pp.1-6, 6 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2015-08-23
Country of Publication
Egypt
No. of Pages
6
Main Subjects
Abstract EN
The main aim of the present study was to assess the antioxidative effects of human umbilical cord-derived mesenchymal stromal cells (UC-MSCs) in a rat model of radiation myelopathy.
UC-MSCs were isolated from Wharton’s jelly (WJ) of umbilical cords.
An irradiated cervical spinal cord rat model (C2-T2 segment) was generated using a 60Co irradiator to deliver 30 Gy of radiation.
UC-MSCs were injected through the tail vein at 90 days, 97 days, 104 days, and 111 days after-irradiation.
Histological damage was examined by cresyl violet/Nissl staining.
The activities of two antioxidant enzymes catalase (CAT) and glutathione peroxidase (GPX) in the spinal cord were measured by the biomedical assay.
In addition, the levels of vascular endothelial growth factor (VEGF) and angiopoietin-2 (Ang-2) in the spinal cord were determined by ELISA methods.
Multiple injections of UC-MSCs through the tail vein ameliorated neuronal damage in the spinal cord, increased the activities of the antioxidant enzymes CAT and GPX, and increased the levels of VEGF and Ang-2 in the spinal cord.
Our results suggest that multiple injections of UC-MSCs via the tail vein in the rat model of radiation myelopathy could significantly improve the antioxidative microenvironment in vivo.
American Psychological Association (APA)
Zhang, Jing& Li, Lian-Bing& Qiu, Zhu& Ren, Hong-Bo& Wu, Jia-Yan& Wang, Tao…[et al.]. 2015. Intravenous Injections of Human Mesenchymal Stromal Cells Modulated the Redox State in a Rat Model of Radiation Myelopathy. Evidence-Based Complementary and Alternative Medicine،Vol. 2015, no. 2015, pp.1-6.
https://search.emarefa.net/detail/BIM-1061499
Modern Language Association (MLA)
Zhang, Jing…[et al.]. Intravenous Injections of Human Mesenchymal Stromal Cells Modulated the Redox State in a Rat Model of Radiation Myelopathy. Evidence-Based Complementary and Alternative Medicine No. 2015 (2015), pp.1-6.
https://search.emarefa.net/detail/BIM-1061499
American Medical Association (AMA)
Zhang, Jing& Li, Lian-Bing& Qiu, Zhu& Ren, Hong-Bo& Wu, Jia-Yan& Wang, Tao…[et al.]. Intravenous Injections of Human Mesenchymal Stromal Cells Modulated the Redox State in a Rat Model of Radiation Myelopathy. Evidence-Based Complementary and Alternative Medicine. 2015. Vol. 2015, no. 2015, pp.1-6.
https://search.emarefa.net/detail/BIM-1061499
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1061499