Antiulcerogenic Activity and Toxicity of Bauhinia holophylla Hydroalcoholic Extract
المؤلفون المشاركون
Vilegas, Wagner
Saldanha, Luiz Leonardo
Dokkedal, Anne Lígia
Souza Brito, Alba Regina Monteiro
Rozza, A. L.
Cesar, D. A. S.
Pieroni, L. G.
Takahira, R. K.
de-Faria, Felipe Meira
Pellizzon, Cláudia Helena
المصدر
Evidence-Based Complementary and Alternative Medicine
العدد
المجلد 2015، العدد 2015 (31 ديسمبر/كانون الأول 2015)، ص ص. 1-9، 9ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2015-04-12
دولة النشر
مصر
عدد الصفحات
9
التخصصات الرئيسية
الملخص EN
Several species of Bauhinia are used in traditional medicine for the treatment of gastrointestinal diseases, diabetes, and inflammation, among other conditions.
The aim of this study was to investigate the antiulcer effect of a hydroalcoholic extract from the leaves of B.
holophylla.
The chemical profile of the extract was determined by HPLC-PAD-ESI-IT-MS.
A dose-effect relation was constructed using the ethanol-induced gastric ulcer model in male Wistar rats.
Histological analyses and studies of antioxidant and anti-inflammatory activities were performed in stomach samples.
The involvement of SH compounds, NO, K+ATP channels, and α2-adrenergic receptors in the gastroprotective effect was evaluated.
A toxicity study was performed with a single oral dose of 5000 mg/kg.
The extract was composed mainly of cyanoglucoside and flavonol-O-glycosides derivatives of quercetin and myricetin.
SH compounds, NO release, K+ATP channel activation, and presynaptic α2-adrenergic receptor stimulation each proved to be involved in the antiulcer effect.
The levels of GSH and activity of GR and GPx were increased, and the levels of TNF-α, IL-6 and IL-10 were modulated.
There was an antidiarrheal effect and there were no signs of toxicity.
B.
holophylla presents antiulcer activity mainly by decreasing oxidative stress and attenuating the inflammatory response, without inducing side effects.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Rozza, A. L.& Cesar, D. A. S.& Pieroni, L. G.& Saldanha, Luiz Leonardo& Dokkedal, Anne Lígia& de-Faria, Felipe Meira…[et al.]. 2015. Antiulcerogenic Activity and Toxicity of Bauhinia holophylla Hydroalcoholic Extract. Evidence-Based Complementary and Alternative Medicine،Vol. 2015, no. 2015, pp.1-9.
https://search.emarefa.net/detail/BIM-1061506
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Rozza, A. L.…[et al.]. Antiulcerogenic Activity and Toxicity of Bauhinia holophylla Hydroalcoholic Extract. Evidence-Based Complementary and Alternative Medicine No. 2015 (2015), pp.1-9.
https://search.emarefa.net/detail/BIM-1061506
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Rozza, A. L.& Cesar, D. A. S.& Pieroni, L. G.& Saldanha, Luiz Leonardo& Dokkedal, Anne Lígia& de-Faria, Felipe Meira…[et al.]. Antiulcerogenic Activity and Toxicity of Bauhinia holophylla Hydroalcoholic Extract. Evidence-Based Complementary and Alternative Medicine. 2015. Vol. 2015, no. 2015, pp.1-9.
https://search.emarefa.net/detail/BIM-1061506
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1061506
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر