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Antiulcerogenic Activity and Toxicity of Bauhinia holophylla Hydroalcoholic Extract
Joint Authors
Vilegas, Wagner
Saldanha, Luiz Leonardo
Dokkedal, Anne Lígia
Souza Brito, Alba Regina Monteiro
Rozza, A. L.
Cesar, D. A. S.
Pieroni, L. G.
Takahira, R. K.
de-Faria, Felipe Meira
Pellizzon, Cláudia Helena
Source
Evidence-Based Complementary and Alternative Medicine
Issue
Vol. 2015, Issue 2015 (31 Dec. 2015), pp.1-9, 9 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2015-04-12
Country of Publication
Egypt
No. of Pages
9
Main Subjects
Abstract EN
Several species of Bauhinia are used in traditional medicine for the treatment of gastrointestinal diseases, diabetes, and inflammation, among other conditions.
The aim of this study was to investigate the antiulcer effect of a hydroalcoholic extract from the leaves of B.
holophylla.
The chemical profile of the extract was determined by HPLC-PAD-ESI-IT-MS.
A dose-effect relation was constructed using the ethanol-induced gastric ulcer model in male Wistar rats.
Histological analyses and studies of antioxidant and anti-inflammatory activities were performed in stomach samples.
The involvement of SH compounds, NO, K+ATP channels, and α2-adrenergic receptors in the gastroprotective effect was evaluated.
A toxicity study was performed with a single oral dose of 5000 mg/kg.
The extract was composed mainly of cyanoglucoside and flavonol-O-glycosides derivatives of quercetin and myricetin.
SH compounds, NO release, K+ATP channel activation, and presynaptic α2-adrenergic receptor stimulation each proved to be involved in the antiulcer effect.
The levels of GSH and activity of GR and GPx were increased, and the levels of TNF-α, IL-6 and IL-10 were modulated.
There was an antidiarrheal effect and there were no signs of toxicity.
B.
holophylla presents antiulcer activity mainly by decreasing oxidative stress and attenuating the inflammatory response, without inducing side effects.
American Psychological Association (APA)
Rozza, A. L.& Cesar, D. A. S.& Pieroni, L. G.& Saldanha, Luiz Leonardo& Dokkedal, Anne Lígia& de-Faria, Felipe Meira…[et al.]. 2015. Antiulcerogenic Activity and Toxicity of Bauhinia holophylla Hydroalcoholic Extract. Evidence-Based Complementary and Alternative Medicine،Vol. 2015, no. 2015, pp.1-9.
https://search.emarefa.net/detail/BIM-1061506
Modern Language Association (MLA)
Rozza, A. L.…[et al.]. Antiulcerogenic Activity and Toxicity of Bauhinia holophylla Hydroalcoholic Extract. Evidence-Based Complementary and Alternative Medicine No. 2015 (2015), pp.1-9.
https://search.emarefa.net/detail/BIM-1061506
American Medical Association (AMA)
Rozza, A. L.& Cesar, D. A. S.& Pieroni, L. G.& Saldanha, Luiz Leonardo& Dokkedal, Anne Lígia& de-Faria, Felipe Meira…[et al.]. Antiulcerogenic Activity and Toxicity of Bauhinia holophylla Hydroalcoholic Extract. Evidence-Based Complementary and Alternative Medicine. 2015. Vol. 2015, no. 2015, pp.1-9.
https://search.emarefa.net/detail/BIM-1061506
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1061506