Metabolomic Analysis of Clinical Plasma from Cerebral Infarction Patients Presenting with Blood Stasis
المؤلفون المشاركون
Kim, Min Jung
Kim, Jin Hee
Jung, Jeeyoun
Kim, Myung-Sunny
Cha, Min Ho
Lee, Myeong Soo
المصدر
Evidence-Based Complementary and Alternative Medicine
العدد
المجلد 2015، العدد 2015 (31 ديسمبر/كانون الأول 2015)، ص ص. 1-7، 7ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2015-03-05
دولة النشر
مصر
عدد الصفحات
7
التخصصات الرئيسية
الملخص EN
Blood stasis (BS) is characterized as a disorder of blood circulation.
In traditional Korean medicine (TKM), it is viewed as a cause factor of diseases such as multiple sclerosis and stroke.
This study investigated differences in the plasma metabolites profiles of subjects displaying BS or non-BS patterns.
Thirty-one patients with cerebral infarction diagnosed with BS and an equal number of sex- and age-matched non-BS patients were enrolled.
Metabolic profiling was performed using UPLC-MS.
The ratio of subjects with a rough pulse and purple coloration of the tongue was higher in patients presenting with BS pattern.
Through metabolomics analysis, 82 metabolites that differed significantly between the BS and non-BS pattern were identified, and the two groups were significantly separated using an orthogonal partial least square-discriminant analysis model (P<0.001).
Of these 82 metabolites, acetyl carnitine, leucine, kynurenine, phosphocholine, hexanoyl carnitine, and decanoyl carnitine were present in significantly higher levels in patients with a BS pattern than those with a non-BS pattern.
Our results also demonstrated that seven plasma metabolites, including acyl-carnitines and kynurenine, were associated with a BS pattern, suggesting that variant plasma metabolic profiles may serve as a biomarker for diagnosis of BS in patients with cerebral infarction.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Cha, Min Ho& Kim, Min Jung& Jung, Jeeyoun& Kim, Jin Hee& Lee, Myeong Soo& Kim, Myung-Sunny. 2015. Metabolomic Analysis of Clinical Plasma from Cerebral Infarction Patients Presenting with Blood Stasis. Evidence-Based Complementary and Alternative Medicine،Vol. 2015, no. 2015, pp.1-7.
https://search.emarefa.net/detail/BIM-1061513
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Cha, Min Ho…[et al.]. Metabolomic Analysis of Clinical Plasma from Cerebral Infarction Patients Presenting with Blood Stasis. Evidence-Based Complementary and Alternative Medicine No. 2015 (2015), pp.1-7.
https://search.emarefa.net/detail/BIM-1061513
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Cha, Min Ho& Kim, Min Jung& Jung, Jeeyoun& Kim, Jin Hee& Lee, Myeong Soo& Kim, Myung-Sunny. Metabolomic Analysis of Clinical Plasma from Cerebral Infarction Patients Presenting with Blood Stasis. Evidence-Based Complementary and Alternative Medicine. 2015. Vol. 2015, no. 2015, pp.1-7.
https://search.emarefa.net/detail/BIM-1061513
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1061513
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر