Metabolomic Analysis of Clinical Plasma from Cerebral Infarction Patients Presenting with Blood Stasis
Joint Authors
Kim, Min Jung
Kim, Jin Hee
Jung, Jeeyoun
Kim, Myung-Sunny
Cha, Min Ho
Lee, Myeong Soo
Source
Evidence-Based Complementary and Alternative Medicine
Issue
Vol. 2015, Issue 2015 (31 Dec. 2015), pp.1-7, 7 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2015-03-05
Country of Publication
Egypt
No. of Pages
7
Main Subjects
Abstract EN
Blood stasis (BS) is characterized as a disorder of blood circulation.
In traditional Korean medicine (TKM), it is viewed as a cause factor of diseases such as multiple sclerosis and stroke.
This study investigated differences in the plasma metabolites profiles of subjects displaying BS or non-BS patterns.
Thirty-one patients with cerebral infarction diagnosed with BS and an equal number of sex- and age-matched non-BS patients were enrolled.
Metabolic profiling was performed using UPLC-MS.
The ratio of subjects with a rough pulse and purple coloration of the tongue was higher in patients presenting with BS pattern.
Through metabolomics analysis, 82 metabolites that differed significantly between the BS and non-BS pattern were identified, and the two groups were significantly separated using an orthogonal partial least square-discriminant analysis model (P<0.001).
Of these 82 metabolites, acetyl carnitine, leucine, kynurenine, phosphocholine, hexanoyl carnitine, and decanoyl carnitine were present in significantly higher levels in patients with a BS pattern than those with a non-BS pattern.
Our results also demonstrated that seven plasma metabolites, including acyl-carnitines and kynurenine, were associated with a BS pattern, suggesting that variant plasma metabolic profiles may serve as a biomarker for diagnosis of BS in patients with cerebral infarction.
American Psychological Association (APA)
Cha, Min Ho& Kim, Min Jung& Jung, Jeeyoun& Kim, Jin Hee& Lee, Myeong Soo& Kim, Myung-Sunny. 2015. Metabolomic Analysis of Clinical Plasma from Cerebral Infarction Patients Presenting with Blood Stasis. Evidence-Based Complementary and Alternative Medicine،Vol. 2015, no. 2015, pp.1-7.
https://search.emarefa.net/detail/BIM-1061513
Modern Language Association (MLA)
Cha, Min Ho…[et al.]. Metabolomic Analysis of Clinical Plasma from Cerebral Infarction Patients Presenting with Blood Stasis. Evidence-Based Complementary and Alternative Medicine No. 2015 (2015), pp.1-7.
https://search.emarefa.net/detail/BIM-1061513
American Medical Association (AMA)
Cha, Min Ho& Kim, Min Jung& Jung, Jeeyoun& Kim, Jin Hee& Lee, Myeong Soo& Kim, Myung-Sunny. Metabolomic Analysis of Clinical Plasma from Cerebral Infarction Patients Presenting with Blood Stasis. Evidence-Based Complementary and Alternative Medicine. 2015. Vol. 2015, no. 2015, pp.1-7.
https://search.emarefa.net/detail/BIM-1061513
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1061513