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Heat-Processed Scutellariae Radix Enhances Anti-Inflammatory Effect against Lipopolysaccharide-Induced Acute Lung Injury in Mice via NF-κB Signaling
المؤلفون المشاركون
Yokozawa, Takako
Shin, Yu Ock
Lee, Gyeong-Hwan
Rhee, Man Hee
Roh, Seong-Soo
Park, Chan Hum
المصدر
Evidence-Based Complementary and Alternative Medicine
العدد
المجلد 2015، العدد 2015 (31 ديسمبر/كانون الأول 2015)، ص ص. 1-12، 12ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2015-06-18
دولة النشر
مصر
عدد الصفحات
12
التخصصات الرئيسية
الملخص EN
The present study was conducted to examine whether heat-processed Scutellariae Radix has an ameliorative effect on lipopolysaccharide- (LPS-) induced acute lung injury in mice.
The effects of Scutellariae Radix heat-processed at 160°C (HSR) were compared with those of nonheat-processed Scutellariae Radix (NSR).
The LPS-treated group displayed a markedly decreased body weight and significantly increased lung weight; however, the administration of NSR or HSR improved both the body and lung weights.
The increased oxidative stress and inflammatory biomarker levels in the serum and lung were reduced significantly with HSR.
The reduced superoxide dismutase and catalase increased significantly by both NSR and HSR.
Also, the dysregulated oxidative stress and inflammation were significantly ameliorated by NSR and HSR.
The expression of inflammatory mediators and cytokines by nuclear factor-kappa B activation was modulated through inhibition of a nuclear factor kappa Bα degradation.
Also, lung histological change was markedly suppressed by HSR rather than NSR.
Overall, the ameliorative effects of HSR were superior to those when being nonheat-processed.
The representative flavonoid contents of Scutellariae Radix that include baicalin, baicalein, and wogonin were greater by heat process.
These data reveal heat-processed Scutellariae Radix may be a critical factor involved in the improvement of lung disorders caused by LPS.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Shin, Yu Ock& Park, Chan Hum& Lee, Gyeong-Hwan& Yokozawa, Takako& Roh, Seong-Soo& Rhee, Man Hee. 2015. Heat-Processed Scutellariae Radix Enhances Anti-Inflammatory Effect against Lipopolysaccharide-Induced Acute Lung Injury in Mice via NF-κB Signaling. Evidence-Based Complementary and Alternative Medicine،Vol. 2015, no. 2015, pp.1-12.
https://search.emarefa.net/detail/BIM-1061517
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Shin, Yu Ock…[et al.]. Heat-Processed Scutellariae Radix Enhances Anti-Inflammatory Effect against Lipopolysaccharide-Induced Acute Lung Injury in Mice via NF-κB Signaling. Evidence-Based Complementary and Alternative Medicine No. 2015 (2015), pp.1-12.
https://search.emarefa.net/detail/BIM-1061517
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Shin, Yu Ock& Park, Chan Hum& Lee, Gyeong-Hwan& Yokozawa, Takako& Roh, Seong-Soo& Rhee, Man Hee. Heat-Processed Scutellariae Radix Enhances Anti-Inflammatory Effect against Lipopolysaccharide-Induced Acute Lung Injury in Mice via NF-κB Signaling. Evidence-Based Complementary and Alternative Medicine. 2015. Vol. 2015, no. 2015, pp.1-12.
https://search.emarefa.net/detail/BIM-1061517
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1061517
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
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