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Heat-Processed Scutellariae Radix Enhances Anti-Inflammatory Effect against Lipopolysaccharide-Induced Acute Lung Injury in Mice via NF-κB Signaling
Joint Authors
Yokozawa, Takako
Shin, Yu Ock
Lee, Gyeong-Hwan
Rhee, Man Hee
Roh, Seong-Soo
Park, Chan Hum
Source
Evidence-Based Complementary and Alternative Medicine
Issue
Vol. 2015, Issue 2015 (31 Dec. 2015), pp.1-12, 12 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2015-06-18
Country of Publication
Egypt
No. of Pages
12
Main Subjects
Abstract EN
The present study was conducted to examine whether heat-processed Scutellariae Radix has an ameliorative effect on lipopolysaccharide- (LPS-) induced acute lung injury in mice.
The effects of Scutellariae Radix heat-processed at 160°C (HSR) were compared with those of nonheat-processed Scutellariae Radix (NSR).
The LPS-treated group displayed a markedly decreased body weight and significantly increased lung weight; however, the administration of NSR or HSR improved both the body and lung weights.
The increased oxidative stress and inflammatory biomarker levels in the serum and lung were reduced significantly with HSR.
The reduced superoxide dismutase and catalase increased significantly by both NSR and HSR.
Also, the dysregulated oxidative stress and inflammation were significantly ameliorated by NSR and HSR.
The expression of inflammatory mediators and cytokines by nuclear factor-kappa B activation was modulated through inhibition of a nuclear factor kappa Bα degradation.
Also, lung histological change was markedly suppressed by HSR rather than NSR.
Overall, the ameliorative effects of HSR were superior to those when being nonheat-processed.
The representative flavonoid contents of Scutellariae Radix that include baicalin, baicalein, and wogonin were greater by heat process.
These data reveal heat-processed Scutellariae Radix may be a critical factor involved in the improvement of lung disorders caused by LPS.
American Psychological Association (APA)
Shin, Yu Ock& Park, Chan Hum& Lee, Gyeong-Hwan& Yokozawa, Takako& Roh, Seong-Soo& Rhee, Man Hee. 2015. Heat-Processed Scutellariae Radix Enhances Anti-Inflammatory Effect against Lipopolysaccharide-Induced Acute Lung Injury in Mice via NF-κB Signaling. Evidence-Based Complementary and Alternative Medicine،Vol. 2015, no. 2015, pp.1-12.
https://search.emarefa.net/detail/BIM-1061517
Modern Language Association (MLA)
Shin, Yu Ock…[et al.]. Heat-Processed Scutellariae Radix Enhances Anti-Inflammatory Effect against Lipopolysaccharide-Induced Acute Lung Injury in Mice via NF-κB Signaling. Evidence-Based Complementary and Alternative Medicine No. 2015 (2015), pp.1-12.
https://search.emarefa.net/detail/BIM-1061517
American Medical Association (AMA)
Shin, Yu Ock& Park, Chan Hum& Lee, Gyeong-Hwan& Yokozawa, Takako& Roh, Seong-Soo& Rhee, Man Hee. Heat-Processed Scutellariae Radix Enhances Anti-Inflammatory Effect against Lipopolysaccharide-Induced Acute Lung Injury in Mice via NF-κB Signaling. Evidence-Based Complementary and Alternative Medicine. 2015. Vol. 2015, no. 2015, pp.1-12.
https://search.emarefa.net/detail/BIM-1061517
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1061517