Gastroprotective Effect of Geopropolis from Melipona scutellaris Is Dependent on Production of Nitric Oxide and Prostaglandin
المؤلفون المشاركون
Rosalen, Pedro Luiz
Ribeiro-Junior, Jerônimo Aparecido
Cavallini, Miriam Elias
Ikegaki, Masaharu
Denny, Carina
de Alencar, Severino Matias
Luiz Rosalen, Pedro
المصدر
Evidence-Based Complementary and Alternative Medicine
العدد
المجلد 2015، العدد 2015 (31 ديسمبر/كانون الأول 2015)، ص ص. 1-5، 5ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2015-04-08
دولة النشر
مصر
عدد الصفحات
5
التخصصات الرئيسية
الملخص EN
The aim of this study was to evaluate the gastroprotective activity of ethanolic extract of geopropolis (EEGP) from Melipona scutellaris and to investigate the possible mechanisms of action.
The gastroprotective activity of the EEGP was evaluated using model ulcer induced by ethanol.
To elucidate the possible mechanisms of action, we investigated the involvement of the nonprotein sulfhydryl (NP-SH) groups, nitric oxide and prostaglandins.
In addition, the antisecretory activity of EEGP was also evaluated by pylorus ligated model.
The EEGP orally administrated (300 mg/kg) reduced the ulcerative lesions induced by the ethanol (P<0.05).
Regarding the mechanism of action, the prior administration of nitric oxide and prostaglandins antagonists suppressed the activity of gastroprotective EEGP (P<0.05).
On the other hand the gastroprotective activity of EEGP was kept in the group pretreated with the antagonist of the NP-SH groups; furthermore the antisecretory activity was not significant (P>0.05).
These results support the alternative medicine use of geopropolis as gastroprotective and the activities observed show to be related to nitric oxide and prostaglandins production.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Ribeiro-Junior, Jerônimo Aparecido& Luiz Rosalen, Pedro& Cavallini, Miriam Elias& Denny, Carina& de Alencar, Severino Matias& Ikegaki, Masaharu…[et al.]. 2015. Gastroprotective Effect of Geopropolis from Melipona scutellaris Is Dependent on Production of Nitric Oxide and Prostaglandin. Evidence-Based Complementary and Alternative Medicine،Vol. 2015, no. 2015, pp.1-5.
https://search.emarefa.net/detail/BIM-1061522
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Ribeiro-Junior, Jerônimo Aparecido…[et al.]. Gastroprotective Effect of Geopropolis from Melipona scutellaris Is Dependent on Production of Nitric Oxide and Prostaglandin. Evidence-Based Complementary and Alternative Medicine No. 2015 (2015), pp.1-5.
https://search.emarefa.net/detail/BIM-1061522
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Ribeiro-Junior, Jerônimo Aparecido& Luiz Rosalen, Pedro& Cavallini, Miriam Elias& Denny, Carina& de Alencar, Severino Matias& Ikegaki, Masaharu…[et al.]. Gastroprotective Effect of Geopropolis from Melipona scutellaris Is Dependent on Production of Nitric Oxide and Prostaglandin. Evidence-Based Complementary and Alternative Medicine. 2015. Vol. 2015, no. 2015, pp.1-5.
https://search.emarefa.net/detail/BIM-1061522
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1061522
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر