Gastroprotective Effect of Geopropolis from Melipona scutellaris Is Dependent on Production of Nitric Oxide and Prostaglandin
Joint Authors
Rosalen, Pedro Luiz
Ribeiro-Junior, Jerônimo Aparecido
Cavallini, Miriam Elias
Ikegaki, Masaharu
Denny, Carina
de Alencar, Severino Matias
Luiz Rosalen, Pedro
Source
Evidence-Based Complementary and Alternative Medicine
Issue
Vol. 2015, Issue 2015 (31 Dec. 2015), pp.1-5, 5 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2015-04-08
Country of Publication
Egypt
No. of Pages
5
Main Subjects
Abstract EN
The aim of this study was to evaluate the gastroprotective activity of ethanolic extract of geopropolis (EEGP) from Melipona scutellaris and to investigate the possible mechanisms of action.
The gastroprotective activity of the EEGP was evaluated using model ulcer induced by ethanol.
To elucidate the possible mechanisms of action, we investigated the involvement of the nonprotein sulfhydryl (NP-SH) groups, nitric oxide and prostaglandins.
In addition, the antisecretory activity of EEGP was also evaluated by pylorus ligated model.
The EEGP orally administrated (300 mg/kg) reduced the ulcerative lesions induced by the ethanol (P<0.05).
Regarding the mechanism of action, the prior administration of nitric oxide and prostaglandins antagonists suppressed the activity of gastroprotective EEGP (P<0.05).
On the other hand the gastroprotective activity of EEGP was kept in the group pretreated with the antagonist of the NP-SH groups; furthermore the antisecretory activity was not significant (P>0.05).
These results support the alternative medicine use of geopropolis as gastroprotective and the activities observed show to be related to nitric oxide and prostaglandins production.
American Psychological Association (APA)
Ribeiro-Junior, Jerônimo Aparecido& Luiz Rosalen, Pedro& Cavallini, Miriam Elias& Denny, Carina& de Alencar, Severino Matias& Ikegaki, Masaharu…[et al.]. 2015. Gastroprotective Effect of Geopropolis from Melipona scutellaris Is Dependent on Production of Nitric Oxide and Prostaglandin. Evidence-Based Complementary and Alternative Medicine،Vol. 2015, no. 2015, pp.1-5.
https://search.emarefa.net/detail/BIM-1061522
Modern Language Association (MLA)
Ribeiro-Junior, Jerônimo Aparecido…[et al.]. Gastroprotective Effect of Geopropolis from Melipona scutellaris Is Dependent on Production of Nitric Oxide and Prostaglandin. Evidence-Based Complementary and Alternative Medicine No. 2015 (2015), pp.1-5.
https://search.emarefa.net/detail/BIM-1061522
American Medical Association (AMA)
Ribeiro-Junior, Jerônimo Aparecido& Luiz Rosalen, Pedro& Cavallini, Miriam Elias& Denny, Carina& de Alencar, Severino Matias& Ikegaki, Masaharu…[et al.]. Gastroprotective Effect of Geopropolis from Melipona scutellaris Is Dependent on Production of Nitric Oxide and Prostaglandin. Evidence-Based Complementary and Alternative Medicine. 2015. Vol. 2015, no. 2015, pp.1-5.
https://search.emarefa.net/detail/BIM-1061522
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1061522