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The Anti-Porcine Parvovirus Activity of Nanometer Propolis Flavone and Propolis Flavone In Vitro and In Vivo
المؤلفون المشاركون
Fan, Yunpeng
Ma, Xia
Guo, Zhenhuan
Shen, Zhiqiang
Wang, Jinliang
Fan, Yunpeng
المصدر
Evidence-Based Complementary and Alternative Medicine
العدد
المجلد 2015، العدد 2015 (31 ديسمبر/كانون الأول 2015)، ص ص. 1-10، 10ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2015-02-26
دولة النشر
مصر
عدد الصفحات
10
التخصصات الرئيسية
الملخص EN
Objectives.
The present study was conducted to evaluate the activity of nanometer propolis flavone (NPF) on inhibiting porcine parvovirus (PPV) in vitro and in vivo.
Methods.
In vitro, the effect of NPF on cellular infectivity of PPV was carried out before and after adding drug and simultaneous adding and PPV after being mixed.
In vivo, the anti-PPV effect of NPF in guinea pigs was performed.
Results.
The results showed that NPF could significantly inhibit PPV infecting porcine kidney- (PK-) 15 cells compared with propolis flavone (PF), and the activity of NPF was the best in preadding drug pattern.
NPF at high and medium doses was able to observably restrain PPV copying in lung, gonad, blood, and spleen, decrease the impact of PPV on weight of guinea pigs, and improve hemagglutination inhibition (HI) of PPV in serum.
In addition, it could also increase the contents of IL-2 and IL-6 in serum after PPV challenge.
Conclusion.
These results indicated that NPF could significantly improve the anti-PPV activity of PF, and its high concentration possessed the best efficacy.
Therefore, NPF would be expected to be exploited into a new-style antiviral drug.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Ma, Xia& Guo, Zhenhuan& Shen, Zhiqiang& Fan, Yunpeng& Wang, Jinliang& Fan, Yunpeng. 2015. The Anti-Porcine Parvovirus Activity of Nanometer Propolis Flavone and Propolis Flavone In Vitro and In Vivo. Evidence-Based Complementary and Alternative Medicine،Vol. 2015, no. 2015, pp.1-10.
https://search.emarefa.net/detail/BIM-1061541
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Ma, Xia…[et al.]. The Anti-Porcine Parvovirus Activity of Nanometer Propolis Flavone and Propolis Flavone In Vitro and In Vivo. Evidence-Based Complementary and Alternative Medicine No. 2015 (2015), pp.1-10.
https://search.emarefa.net/detail/BIM-1061541
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Ma, Xia& Guo, Zhenhuan& Shen, Zhiqiang& Fan, Yunpeng& Wang, Jinliang& Fan, Yunpeng. The Anti-Porcine Parvovirus Activity of Nanometer Propolis Flavone and Propolis Flavone In Vitro and In Vivo. Evidence-Based Complementary and Alternative Medicine. 2015. Vol. 2015, no. 2015, pp.1-10.
https://search.emarefa.net/detail/BIM-1061541
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1061541
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
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