The Anti-Porcine Parvovirus Activity of Nanometer Propolis Flavone and Propolis Flavone In Vitro and In Vivo
Joint Authors
Fan, Yunpeng
Ma, Xia
Guo, Zhenhuan
Shen, Zhiqiang
Wang, Jinliang
Fan, Yunpeng
Source
Evidence-Based Complementary and Alternative Medicine
Issue
Vol. 2015, Issue 2015 (31 Dec. 2015), pp.1-10, 10 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2015-02-26
Country of Publication
Egypt
No. of Pages
10
Main Subjects
Abstract EN
Objectives.
The present study was conducted to evaluate the activity of nanometer propolis flavone (NPF) on inhibiting porcine parvovirus (PPV) in vitro and in vivo.
Methods.
In vitro, the effect of NPF on cellular infectivity of PPV was carried out before and after adding drug and simultaneous adding and PPV after being mixed.
In vivo, the anti-PPV effect of NPF in guinea pigs was performed.
Results.
The results showed that NPF could significantly inhibit PPV infecting porcine kidney- (PK-) 15 cells compared with propolis flavone (PF), and the activity of NPF was the best in preadding drug pattern.
NPF at high and medium doses was able to observably restrain PPV copying in lung, gonad, blood, and spleen, decrease the impact of PPV on weight of guinea pigs, and improve hemagglutination inhibition (HI) of PPV in serum.
In addition, it could also increase the contents of IL-2 and IL-6 in serum after PPV challenge.
Conclusion.
These results indicated that NPF could significantly improve the anti-PPV activity of PF, and its high concentration possessed the best efficacy.
Therefore, NPF would be expected to be exploited into a new-style antiviral drug.
American Psychological Association (APA)
Ma, Xia& Guo, Zhenhuan& Shen, Zhiqiang& Fan, Yunpeng& Wang, Jinliang& Fan, Yunpeng. 2015. The Anti-Porcine Parvovirus Activity of Nanometer Propolis Flavone and Propolis Flavone In Vitro and In Vivo. Evidence-Based Complementary and Alternative Medicine،Vol. 2015, no. 2015, pp.1-10.
https://search.emarefa.net/detail/BIM-1061541
Modern Language Association (MLA)
Ma, Xia…[et al.]. The Anti-Porcine Parvovirus Activity of Nanometer Propolis Flavone and Propolis Flavone In Vitro and In Vivo. Evidence-Based Complementary and Alternative Medicine No. 2015 (2015), pp.1-10.
https://search.emarefa.net/detail/BIM-1061541
American Medical Association (AMA)
Ma, Xia& Guo, Zhenhuan& Shen, Zhiqiang& Fan, Yunpeng& Wang, Jinliang& Fan, Yunpeng. The Anti-Porcine Parvovirus Activity of Nanometer Propolis Flavone and Propolis Flavone In Vitro and In Vivo. Evidence-Based Complementary and Alternative Medicine. 2015. Vol. 2015, no. 2015, pp.1-10.
https://search.emarefa.net/detail/BIM-1061541
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1061541