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Oldenlandia diffusa Promotes Antiproliferative and Apoptotic Effects in a Rat Hepatocellular Carcinoma with Liver Cirrhosis
المؤلفون المشاركون
Maeng, Lee-So
Jung, Yu Jin
Park, Moon-Seo
Shin, Hak Soo
Lee, Jisoo
Lee, Jin-Hee
Jung, Ho Yong
Park, Sang In
Chung, Young-An
Sunwoo, Yun-Young
Han, Young-Min
المصدر
Evidence-Based Complementary and Alternative Medicine
العدد
المجلد 2015، العدد 2015 (31 ديسمبر/كانون الأول 2015)، ص ص. 1-11، 11ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2015-03-10
دولة النشر
مصر
عدد الصفحات
11
التخصصات الرئيسية
الملخص EN
Oldenlandia diffusa (OD) is commonly used with various diseases such as cancer, arthritis, and autoimmune disease.
Liver cirrhosis is a predominant risk factor for hepatocellular carcinoma (HCC).
Here, we show that the therapeutic effect of OD, which was investigated both in vitro and chemically, induced HCC model.
OD significantly enhanced apoptosis and antiproliferative activity and reduced migration ability of HCC cells.
In vivo, OD was treated twice a day for 28 days after confirmed HCC model through 2-[18F]-fluoro-2-deoxy-D-glucose (18F-FDG) imaging.
The survival in OD treated groups was shown to have a greater therapeutic effect than the control group.
28 days after OD treatment, OD treated groups resulted in a significant reduction in tumor number, size, 18F-FDG uptake, and serum levels such as alanine transaminase, aspartate transaminase, and alkaline phosphate compared to the control group.
Also, proliferated cells in tumor sites by OD were reduced compared to the control group.
Furthermore, several rats in OD treated group survived over 60 days and liver morphology of these rats showed the difference between tumor mass and normal tissue.
These results suggest that OD may have antiproliferative activity, inhibition of metastasis, and apoptotic effects in chemically induced HCC model and can have the potential use for clinical application as anticancer drug of the herbal extract.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Sunwoo, Yun-Young& Lee, Jin-Hee& Jung, Ho Yong& Jung, Yu Jin& Park, Moon-Seo& Chung, Young-An…[et al.]. 2015. Oldenlandia diffusa Promotes Antiproliferative and Apoptotic Effects in a Rat Hepatocellular Carcinoma with Liver Cirrhosis. Evidence-Based Complementary and Alternative Medicine،Vol. 2015, no. 2015, pp.1-11.
https://search.emarefa.net/detail/BIM-1061564
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Sunwoo, Yun-Young…[et al.]. Oldenlandia diffusa Promotes Antiproliferative and Apoptotic Effects in a Rat Hepatocellular Carcinoma with Liver Cirrhosis. Evidence-Based Complementary and Alternative Medicine No. 2015 (2015), pp.1-11.
https://search.emarefa.net/detail/BIM-1061564
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Sunwoo, Yun-Young& Lee, Jin-Hee& Jung, Ho Yong& Jung, Yu Jin& Park, Moon-Seo& Chung, Young-An…[et al.]. Oldenlandia diffusa Promotes Antiproliferative and Apoptotic Effects in a Rat Hepatocellular Carcinoma with Liver Cirrhosis. Evidence-Based Complementary and Alternative Medicine. 2015. Vol. 2015, no. 2015, pp.1-11.
https://search.emarefa.net/detail/BIM-1061564
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1061564
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
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