Oldenlandia diffusa Promotes Antiproliferative and Apoptotic Effects in a Rat Hepatocellular Carcinoma with Liver Cirrhosis
Joint Authors
Maeng, Lee-So
Jung, Yu Jin
Park, Moon-Seo
Shin, Hak Soo
Lee, Jisoo
Lee, Jin-Hee
Jung, Ho Yong
Park, Sang In
Chung, Young-An
Sunwoo, Yun-Young
Han, Young-Min
Source
Evidence-Based Complementary and Alternative Medicine
Issue
Vol. 2015, Issue 2015 (31 Dec. 2015), pp.1-11, 11 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2015-03-10
Country of Publication
Egypt
No. of Pages
11
Main Subjects
Abstract EN
Oldenlandia diffusa (OD) is commonly used with various diseases such as cancer, arthritis, and autoimmune disease.
Liver cirrhosis is a predominant risk factor for hepatocellular carcinoma (HCC).
Here, we show that the therapeutic effect of OD, which was investigated both in vitro and chemically, induced HCC model.
OD significantly enhanced apoptosis and antiproliferative activity and reduced migration ability of HCC cells.
In vivo, OD was treated twice a day for 28 days after confirmed HCC model through 2-[18F]-fluoro-2-deoxy-D-glucose (18F-FDG) imaging.
The survival in OD treated groups was shown to have a greater therapeutic effect than the control group.
28 days after OD treatment, OD treated groups resulted in a significant reduction in tumor number, size, 18F-FDG uptake, and serum levels such as alanine transaminase, aspartate transaminase, and alkaline phosphate compared to the control group.
Also, proliferated cells in tumor sites by OD were reduced compared to the control group.
Furthermore, several rats in OD treated group survived over 60 days and liver morphology of these rats showed the difference between tumor mass and normal tissue.
These results suggest that OD may have antiproliferative activity, inhibition of metastasis, and apoptotic effects in chemically induced HCC model and can have the potential use for clinical application as anticancer drug of the herbal extract.
American Psychological Association (APA)
Sunwoo, Yun-Young& Lee, Jin-Hee& Jung, Ho Yong& Jung, Yu Jin& Park, Moon-Seo& Chung, Young-An…[et al.]. 2015. Oldenlandia diffusa Promotes Antiproliferative and Apoptotic Effects in a Rat Hepatocellular Carcinoma with Liver Cirrhosis. Evidence-Based Complementary and Alternative Medicine،Vol. 2015, no. 2015, pp.1-11.
https://search.emarefa.net/detail/BIM-1061564
Modern Language Association (MLA)
Sunwoo, Yun-Young…[et al.]. Oldenlandia diffusa Promotes Antiproliferative and Apoptotic Effects in a Rat Hepatocellular Carcinoma with Liver Cirrhosis. Evidence-Based Complementary and Alternative Medicine No. 2015 (2015), pp.1-11.
https://search.emarefa.net/detail/BIM-1061564
American Medical Association (AMA)
Sunwoo, Yun-Young& Lee, Jin-Hee& Jung, Ho Yong& Jung, Yu Jin& Park, Moon-Seo& Chung, Young-An…[et al.]. Oldenlandia diffusa Promotes Antiproliferative and Apoptotic Effects in a Rat Hepatocellular Carcinoma with Liver Cirrhosis. Evidence-Based Complementary and Alternative Medicine. 2015. Vol. 2015, no. 2015, pp.1-11.
https://search.emarefa.net/detail/BIM-1061564
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1061564