The Mechanism Research of Qishen Yiqi Formula by Module-Network Analysis
المؤلفون المشاركون
Zheng, Shichao
Zhang, Yanling
Qiao, Yanjiang
المصدر
Evidence-Based Complementary and Alternative Medicine
العدد
المجلد 2015، العدد 2015 (31 ديسمبر/كانون الأول 2015)، ص ص. 1-12، 12ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2015-08-24
دولة النشر
مصر
عدد الصفحات
12
التخصصات الرئيسية
الملخص EN
Qishen Yiqi formula (QSYQ) has the effect of tonifying Qi and promoting blood circulation, which is widely used to treat the cardiovascular diseases with Qi deficiency and blood stasis syndrome.
However, the mechanism of QSYQ to tonify Qi and promote blood circulation is rarely reported at molecular or systems level.
This study aimed to elucidate the mechanism of QSYQ based on the protein interaction network (PIN) analysis.
The targets’ information of the active components was obtained from ChEMBL and STITCH databases and was further used to search against protein-protein interactions by String database.
Next, the PINs of QSYQ were constructed by Cytoscape and were analyzed by gene ontology enrichment analysis based on Markov Cluster algorithm.
Finally, based on the topological parameters, the properties of scale-free, small world, and modularity of the QSYQ’s PINs were analyzed.
And based on function modules, the mechanism of QSYQ was elucidated.
The results indicated that Qi-tonifying efficacy of QSYQ may be partly attributed to the regulation of amino acid metabolism, carbohydrate metabolism, lipid metabolism, and cAMP metabolism, while QSYQ improves the blood stasis through the regulation of blood coagulation and cardiac muscle contraction.
Meanwhile, the “synergy” of formula compatibility was also illuminated.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Zheng, Shichao& Zhang, Yanling& Qiao, Yanjiang. 2015. The Mechanism Research of Qishen Yiqi Formula by Module-Network Analysis. Evidence-Based Complementary and Alternative Medicine،Vol. 2015, no. 2015, pp.1-12.
https://search.emarefa.net/detail/BIM-1062385
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Zheng, Shichao…[et al.]. The Mechanism Research of Qishen Yiqi Formula by Module-Network Analysis. Evidence-Based Complementary and Alternative Medicine No. 2015 (2015), pp.1-12.
https://search.emarefa.net/detail/BIM-1062385
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Zheng, Shichao& Zhang, Yanling& Qiao, Yanjiang. The Mechanism Research of Qishen Yiqi Formula by Module-Network Analysis. Evidence-Based Complementary and Alternative Medicine. 2015. Vol. 2015, no. 2015, pp.1-12.
https://search.emarefa.net/detail/BIM-1062385
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1062385
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر