The Mechanism Research of Qishen Yiqi Formula by Module-Network Analysis
Joint Authors
Zheng, Shichao
Zhang, Yanling
Qiao, Yanjiang
Source
Evidence-Based Complementary and Alternative Medicine
Issue
Vol. 2015, Issue 2015 (31 Dec. 2015), pp.1-12, 12 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2015-08-24
Country of Publication
Egypt
No. of Pages
12
Main Subjects
Abstract EN
Qishen Yiqi formula (QSYQ) has the effect of tonifying Qi and promoting blood circulation, which is widely used to treat the cardiovascular diseases with Qi deficiency and blood stasis syndrome.
However, the mechanism of QSYQ to tonify Qi and promote blood circulation is rarely reported at molecular or systems level.
This study aimed to elucidate the mechanism of QSYQ based on the protein interaction network (PIN) analysis.
The targets’ information of the active components was obtained from ChEMBL and STITCH databases and was further used to search against protein-protein interactions by String database.
Next, the PINs of QSYQ were constructed by Cytoscape and were analyzed by gene ontology enrichment analysis based on Markov Cluster algorithm.
Finally, based on the topological parameters, the properties of scale-free, small world, and modularity of the QSYQ’s PINs were analyzed.
And based on function modules, the mechanism of QSYQ was elucidated.
The results indicated that Qi-tonifying efficacy of QSYQ may be partly attributed to the regulation of amino acid metabolism, carbohydrate metabolism, lipid metabolism, and cAMP metabolism, while QSYQ improves the blood stasis through the regulation of blood coagulation and cardiac muscle contraction.
Meanwhile, the “synergy” of formula compatibility was also illuminated.
American Psychological Association (APA)
Zheng, Shichao& Zhang, Yanling& Qiao, Yanjiang. 2015. The Mechanism Research of Qishen Yiqi Formula by Module-Network Analysis. Evidence-Based Complementary and Alternative Medicine،Vol. 2015, no. 2015, pp.1-12.
https://search.emarefa.net/detail/BIM-1062385
Modern Language Association (MLA)
Zheng, Shichao…[et al.]. The Mechanism Research of Qishen Yiqi Formula by Module-Network Analysis. Evidence-Based Complementary and Alternative Medicine No. 2015 (2015), pp.1-12.
https://search.emarefa.net/detail/BIM-1062385
American Medical Association (AMA)
Zheng, Shichao& Zhang, Yanling& Qiao, Yanjiang. The Mechanism Research of Qishen Yiqi Formula by Module-Network Analysis. Evidence-Based Complementary and Alternative Medicine. 2015. Vol. 2015, no. 2015, pp.1-12.
https://search.emarefa.net/detail/BIM-1062385
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1062385