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Phosphodiesterase-1 Inhibitory Activity of Two Flavonoids Isolated from Pistacia integerrima J. L. Stewart Galls
المؤلفون المشاركون
Mascolo, Nicola
Khan, Haroon
Rauf, Abdur
Saleem, Muhammad
Uddin, Ghias
Siddiqui, Bina S.
Raza, Muslim
Hamid, Syeda Zehra
Maione, Francesco
De Feo, Vincenzo
Khan, Ajmal
المصدر
Evidence-Based Complementary and Alternative Medicine
العدد
المجلد 2015، العدد 2015 (31 ديسمبر/كانون الأول 2015)، ص ص. 1-6، 6ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2015-04-05
دولة النشر
مصر
عدد الصفحات
6
التخصصات الرئيسية
الملخص EN
Pistacia integerrima is one of twenty species among the genus Pistacia.
Long horn-shaped galls that develop on this plant are harvested and used in Ayurveda and Indian traditional medicine to make “karkatshringi”, a herbal medicine used for the treatment of asthma and different disorders of respiratory tract.
However, until now, the molecular mechanisms of action of “karkatshringi” and its chemical characterization are partially known.
This study deals with the isolation and characterization of the active constituents from the methanolic extract of P.
integerrima galls and it was also oriented to evaluate in vitro and in silico their potential enzymatic inhibitory activity against phosphodiesterase-1 (PDE1), a well-known enzyme involved in airway smooth muscle activity and airway inflammation.
Our results showed that the methanolic extract of P.
integerrima galls and some of its active constituents [naringenin (1) and 3,5,7,4′-tetrahydroxy-flavanone (2)] are able in vitro to inhibit PDE1 activity (59.20 ± 4.95%, 75.90 ± 5.90%, and 65.25 ± 5.25%, resp.) and demonstrate in silico an interesting interaction with this enzymatic site.
Taken together, our results add new knowledge of chemical constituents responsible for the biological activity of P.
integerrima and contextually legitimate the use of this plant in folk medicine.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Rauf, Abdur& Saleem, Muhammad& Uddin, Ghias& Siddiqui, Bina S.& Khan, Haroon& Raza, Muslim…[et al.]. 2015. Phosphodiesterase-1 Inhibitory Activity of Two Flavonoids Isolated from Pistacia integerrima J. L. Stewart Galls. Evidence-Based Complementary and Alternative Medicine،Vol. 2015, no. 2015, pp.1-6.
https://search.emarefa.net/detail/BIM-1062395
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Rauf, Abdur…[et al.]. Phosphodiesterase-1 Inhibitory Activity of Two Flavonoids Isolated from Pistacia integerrima J. L. Stewart Galls. Evidence-Based Complementary and Alternative Medicine No. 2015 (2015), pp.1-6.
https://search.emarefa.net/detail/BIM-1062395
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Rauf, Abdur& Saleem, Muhammad& Uddin, Ghias& Siddiqui, Bina S.& Khan, Haroon& Raza, Muslim…[et al.]. Phosphodiesterase-1 Inhibitory Activity of Two Flavonoids Isolated from Pistacia integerrima J. L. Stewart Galls. Evidence-Based Complementary and Alternative Medicine. 2015. Vol. 2015, no. 2015, pp.1-6.
https://search.emarefa.net/detail/BIM-1062395
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1062395
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
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