Phosphodiesterase-1 Inhibitory Activity of Two Flavonoids Isolated from Pistacia integerrima J. L. Stewart Galls
Joint Authors
Mascolo, Nicola
Khan, Haroon
Rauf, Abdur
Saleem, Muhammad
Uddin, Ghias
Siddiqui, Bina S.
Raza, Muslim
Hamid, Syeda Zehra
Maione, Francesco
De Feo, Vincenzo
Khan, Ajmal
Source
Evidence-Based Complementary and Alternative Medicine
Issue
Vol. 2015, Issue 2015 (31 Dec. 2015), pp.1-6, 6 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2015-04-05
Country of Publication
Egypt
No. of Pages
6
Main Subjects
Abstract EN
Pistacia integerrima is one of twenty species among the genus Pistacia.
Long horn-shaped galls that develop on this plant are harvested and used in Ayurveda and Indian traditional medicine to make “karkatshringi”, a herbal medicine used for the treatment of asthma and different disorders of respiratory tract.
However, until now, the molecular mechanisms of action of “karkatshringi” and its chemical characterization are partially known.
This study deals with the isolation and characterization of the active constituents from the methanolic extract of P.
integerrima galls and it was also oriented to evaluate in vitro and in silico their potential enzymatic inhibitory activity against phosphodiesterase-1 (PDE1), a well-known enzyme involved in airway smooth muscle activity and airway inflammation.
Our results showed that the methanolic extract of P.
integerrima galls and some of its active constituents [naringenin (1) and 3,5,7,4′-tetrahydroxy-flavanone (2)] are able in vitro to inhibit PDE1 activity (59.20 ± 4.95%, 75.90 ± 5.90%, and 65.25 ± 5.25%, resp.) and demonstrate in silico an interesting interaction with this enzymatic site.
Taken together, our results add new knowledge of chemical constituents responsible for the biological activity of P.
integerrima and contextually legitimate the use of this plant in folk medicine.
American Psychological Association (APA)
Rauf, Abdur& Saleem, Muhammad& Uddin, Ghias& Siddiqui, Bina S.& Khan, Haroon& Raza, Muslim…[et al.]. 2015. Phosphodiesterase-1 Inhibitory Activity of Two Flavonoids Isolated from Pistacia integerrima J. L. Stewart Galls. Evidence-Based Complementary and Alternative Medicine،Vol. 2015, no. 2015, pp.1-6.
https://search.emarefa.net/detail/BIM-1062395
Modern Language Association (MLA)
Rauf, Abdur…[et al.]. Phosphodiesterase-1 Inhibitory Activity of Two Flavonoids Isolated from Pistacia integerrima J. L. Stewart Galls. Evidence-Based Complementary and Alternative Medicine No. 2015 (2015), pp.1-6.
https://search.emarefa.net/detail/BIM-1062395
American Medical Association (AMA)
Rauf, Abdur& Saleem, Muhammad& Uddin, Ghias& Siddiqui, Bina S.& Khan, Haroon& Raza, Muslim…[et al.]. Phosphodiesterase-1 Inhibitory Activity of Two Flavonoids Isolated from Pistacia integerrima J. L. Stewart Galls. Evidence-Based Complementary and Alternative Medicine. 2015. Vol. 2015, no. 2015, pp.1-6.
https://search.emarefa.net/detail/BIM-1062395
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1062395