Kushenin Combined with Nucleos(t)ide Analogues for Chronic Hepatitis B: A Systematic Review and Meta-Analysis
المؤلفون المشاركون
Ma, Xiao
Chen, Zhe
Zhao, Yanling
Zhang, Yaming
Zhu, Yun
Wang, Lifu
Chen, Chang
Wei, Shizhang
Yang, Zhirui
Gong, Man
Shen, Honghui
Bai, Zhaofang
Guo, Yuming
Niu, Ming
Xiao, Xiaohe
Wang, Jia-Bo
المصدر
Evidence-Based Complementary and Alternative Medicine
العدد
المجلد 2015، العدد 2015 (31 ديسمبر/كانون الأول 2015)، ص ص. 1-12، 12ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2015-08-11
دولة النشر
مصر
عدد الصفحات
12
التخصصات الرئيسية
الملخص EN
Objective.
To evaluate the efficacy and safety of Kushenin (KS) combined with nucleoside analogues (NAs) for chronic hepatitis B (CHB).
Methods.
Randomized controlled trials (RCTs) of KS combined with NAs for CHB were identified through 7 databases.
Frequencies of loss of serum HBeAg, HBeAg seroconversion, undetectable serum HBV-DNA, ALT normalization, and adverse events at 48 weeks were abstracted by two reviewers.
The Cochrane software was performed to assess the risk of bias in the included trials.
Data were analyzed with Review Manager 5.3 software.
Results.
18 RCTs involving 1684 subjects with CHB were included in the analysis.
KS combined with NAs including lamivudine (LAM), entecavir (ETV), adefovir dipivoxil (ADV), and telbivudine (TLV) showed different degree of improvement in CHB indices.
KS combined with NAs increased the frequency of loss of serum HBeAg, HBeAg seroconversion, undetectable HBV-DNA levels, and ALT normalization compared with single agents.
It also decreased serum ALT and AST level after one-year treatment.
However, KS combined with TLV did not show a significant difference in CHB indices.
The side-effects of KS combined with NAs were light and of low frequency.
Conclusion.
KS combined with NAs improves the efficacy of NAs in CHB.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Chen, Zhe& Ma, Xiao& Zhao, Yanling& Wang, Jia-Bo& Zhang, Yaming& Zhu, Yun…[et al.]. 2015. Kushenin Combined with Nucleos(t)ide Analogues for Chronic Hepatitis B: A Systematic Review and Meta-Analysis. Evidence-Based Complementary and Alternative Medicine،Vol. 2015, no. 2015, pp.1-12.
https://search.emarefa.net/detail/BIM-1062483
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Chen, Zhe…[et al.]. Kushenin Combined with Nucleos(t)ide Analogues for Chronic Hepatitis B: A Systematic Review and Meta-Analysis. Evidence-Based Complementary and Alternative Medicine No. 2015 (2015), pp.1-12.
https://search.emarefa.net/detail/BIM-1062483
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Chen, Zhe& Ma, Xiao& Zhao, Yanling& Wang, Jia-Bo& Zhang, Yaming& Zhu, Yun…[et al.]. Kushenin Combined with Nucleos(t)ide Analogues for Chronic Hepatitis B: A Systematic Review and Meta-Analysis. Evidence-Based Complementary and Alternative Medicine. 2015. Vol. 2015, no. 2015, pp.1-12.
https://search.emarefa.net/detail/BIM-1062483
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1062483
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر