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Kushenin Combined with Nucleos(t)ide Analogues for Chronic Hepatitis B: A Systematic Review and Meta-Analysis
Joint Authors
Ma, Xiao
Chen, Zhe
Zhao, Yanling
Zhang, Yaming
Zhu, Yun
Wang, Lifu
Chen, Chang
Wei, Shizhang
Yang, Zhirui
Gong, Man
Shen, Honghui
Bai, Zhaofang
Guo, Yuming
Niu, Ming
Xiao, Xiaohe
Wang, Jia-Bo
Source
Evidence-Based Complementary and Alternative Medicine
Issue
Vol. 2015, Issue 2015 (31 Dec. 2015), pp.1-12, 12 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2015-08-11
Country of Publication
Egypt
No. of Pages
12
Main Subjects
Abstract EN
Objective.
To evaluate the efficacy and safety of Kushenin (KS) combined with nucleoside analogues (NAs) for chronic hepatitis B (CHB).
Methods.
Randomized controlled trials (RCTs) of KS combined with NAs for CHB were identified through 7 databases.
Frequencies of loss of serum HBeAg, HBeAg seroconversion, undetectable serum HBV-DNA, ALT normalization, and adverse events at 48 weeks were abstracted by two reviewers.
The Cochrane software was performed to assess the risk of bias in the included trials.
Data were analyzed with Review Manager 5.3 software.
Results.
18 RCTs involving 1684 subjects with CHB were included in the analysis.
KS combined with NAs including lamivudine (LAM), entecavir (ETV), adefovir dipivoxil (ADV), and telbivudine (TLV) showed different degree of improvement in CHB indices.
KS combined with NAs increased the frequency of loss of serum HBeAg, HBeAg seroconversion, undetectable HBV-DNA levels, and ALT normalization compared with single agents.
It also decreased serum ALT and AST level after one-year treatment.
However, KS combined with TLV did not show a significant difference in CHB indices.
The side-effects of KS combined with NAs were light and of low frequency.
Conclusion.
KS combined with NAs improves the efficacy of NAs in CHB.
American Psychological Association (APA)
Chen, Zhe& Ma, Xiao& Zhao, Yanling& Wang, Jia-Bo& Zhang, Yaming& Zhu, Yun…[et al.]. 2015. Kushenin Combined with Nucleos(t)ide Analogues for Chronic Hepatitis B: A Systematic Review and Meta-Analysis. Evidence-Based Complementary and Alternative Medicine،Vol. 2015, no. 2015, pp.1-12.
https://search.emarefa.net/detail/BIM-1062483
Modern Language Association (MLA)
Chen, Zhe…[et al.]. Kushenin Combined with Nucleos(t)ide Analogues for Chronic Hepatitis B: A Systematic Review and Meta-Analysis. Evidence-Based Complementary and Alternative Medicine No. 2015 (2015), pp.1-12.
https://search.emarefa.net/detail/BIM-1062483
American Medical Association (AMA)
Chen, Zhe& Ma, Xiao& Zhao, Yanling& Wang, Jia-Bo& Zhang, Yaming& Zhu, Yun…[et al.]. Kushenin Combined with Nucleos(t)ide Analogues for Chronic Hepatitis B: A Systematic Review and Meta-Analysis. Evidence-Based Complementary and Alternative Medicine. 2015. Vol. 2015, no. 2015, pp.1-12.
https://search.emarefa.net/detail/BIM-1062483
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1062483