Neuroprotection of Sanhua Decoction against Focal Cerebral IschemiaReperfusion Injury in Rats through a Mechanism Targeting Aquaporin 4
المؤلفون المشاركون
Li, Ji-huang
Li, Hui-qin
Liu, Ai-ju
Zheng, Guo-qing
Lu, Lin
المصدر
Evidence-Based Complementary and Alternative Medicine
العدد
المجلد 2015، العدد 2015 (31 ديسمبر/كانون الأول 2015)، ص ص. 1-7، 7ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2015-05-18
دولة النشر
مصر
عدد الصفحات
7
التخصصات الرئيسية
الملخص EN
Sanhua decoction (SHD) is a famous classic Chinese herbal prescription for ischemic stroke, and aquaporin 4 (AQP4) is reported to play a key role in ischemic brain edema.
This study aimed to investigate neuroprotection of SHD against focal cerebral ischemia/reperfusion (I/R) injury in rats and explore the hypothesis that AQP4 probably is the target of SHD neuroprotection against I/R rats.
Lentiviral-mediated AQP4-siRNA was inducted into adult male Sprague-Dawley rats via intracerebroventricular injection.
The focal cerebral ischemia/reperfusion model was established by occluding middle cerebral artery.
Neurological examinations were performed according to Longa Scale.
Brain water content, was determined by wet and dry weight measurement.
Western blot was adopted to test the AQP4 expression in ipsilateral hippocampus.
After the treatment, SHD alleviated neurological deficits, reduced brain water content and downregulated the expression of AQP4 at different time points following I/R injury.
Furthermore, neurobehavioral function and brain edema after I/R were significantly attenuated via downregulation of AQP4 expression when combined with AQP4-siRNA technology.
In conclusion, SHD exerted neuroprotection against focal cerebral I/R injury in rats mainly through a mechanism targeting AQP4.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Lu, Lin& Li, Hui-qin& Li, Ji-huang& Liu, Ai-ju& Zheng, Guo-qing. 2015. Neuroprotection of Sanhua Decoction against Focal Cerebral IschemiaReperfusion Injury in Rats through a Mechanism Targeting Aquaporin 4. Evidence-Based Complementary and Alternative Medicine،Vol. 2015, no. 2015, pp.1-7.
https://search.emarefa.net/detail/BIM-1063351
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Lu, Lin…[et al.]. Neuroprotection of Sanhua Decoction against Focal Cerebral IschemiaReperfusion Injury in Rats through a Mechanism Targeting Aquaporin 4. Evidence-Based Complementary and Alternative Medicine No. 2015 (2015), pp.1-7.
https://search.emarefa.net/detail/BIM-1063351
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Lu, Lin& Li, Hui-qin& Li, Ji-huang& Liu, Ai-ju& Zheng, Guo-qing. Neuroprotection of Sanhua Decoction against Focal Cerebral IschemiaReperfusion Injury in Rats through a Mechanism Targeting Aquaporin 4. Evidence-Based Complementary and Alternative Medicine. 2015. Vol. 2015, no. 2015, pp.1-7.
https://search.emarefa.net/detail/BIM-1063351
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1063351
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر