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Effect of Sterols Isolated from Myrtillocactus geometrizans on Growth Inhibition of Colon and Breast Cancer Cells
المؤلفون المشاركون
Bolaños-Carrillo, Mario Augusto
Ventura-Gallegos, Jose Luis
Saldivar-Jiménez, Arturo David
Zentella-Dehesa, Alejandro
Martínez-Vázquez, Mariano
المصدر
Evidence-Based Complementary and Alternative Medicine
العدد
المجلد 2015، العدد 2015 (31 ديسمبر/كانون الأول 2015)، ص ص. 1-9، 9ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2015-05-31
دولة النشر
مصر
عدد الصفحات
9
التخصصات الرئيسية
الملخص EN
Objective.
To explore the effect of peniocerol and macdougallin on HCT-15 and MCF-7 cells proliferation, cell cycle, apoptosis, and PARP cleavage.
Methods.
HCT-15 and MCF-7 cells were treated with various concentrations of peniocerol and macdougallin (10–80 μM) during 24 or 48 h.
Crystal Violet Assay was used to evaluate the inhibition effect.
Cell cycle regulation was examined by a propidium iodide method.
Cell apoptosis was detected through both Annexin–V FLUOS/PI double-labeled cytometry assays and Western blot was applied to assess PARP cleavage.
Results.
Peniocerol and macdougallin induced growth inhibition and apoptosis in vitro in a time- and dose-dependent manner.
Moreover, peniocerol and macdougallin induced arrest of cell cycle-dependent manner and increased the proportion of cells in G0/G1 phase.
PARP cleavage in HCT-15 and MCF-7 cells was induced by treatment with peniocerol and macdougallin after 36 hours.
Conclusions.
Our results showed that the mechanism of cytotoxicity displayed by peniocerol and macdougallin is related to cell cycle arrest and apoptosis in both cell lines.
This is a significant observation because it helps to understand the way some oxysterols isolated from Myrtillocactus geometrizans develop their biological activities against cancer cells.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Bolaños-Carrillo, Mario Augusto& Ventura-Gallegos, Jose Luis& Saldivar-Jiménez, Arturo David& Zentella-Dehesa, Alejandro& Martínez-Vázquez, Mariano. 2015. Effect of Sterols Isolated from Myrtillocactus geometrizans on Growth Inhibition of Colon and Breast Cancer Cells. Evidence-Based Complementary and Alternative Medicine،Vol. 2015, no. 2015, pp.1-9.
https://search.emarefa.net/detail/BIM-1063355
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Bolaños-Carrillo, Mario Augusto…[et al.]. Effect of Sterols Isolated from Myrtillocactus geometrizans on Growth Inhibition of Colon and Breast Cancer Cells. Evidence-Based Complementary and Alternative Medicine No. 2015 (2015), pp.1-9.
https://search.emarefa.net/detail/BIM-1063355
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Bolaños-Carrillo, Mario Augusto& Ventura-Gallegos, Jose Luis& Saldivar-Jiménez, Arturo David& Zentella-Dehesa, Alejandro& Martínez-Vázquez, Mariano. Effect of Sterols Isolated from Myrtillocactus geometrizans on Growth Inhibition of Colon and Breast Cancer Cells. Evidence-Based Complementary and Alternative Medicine. 2015. Vol. 2015, no. 2015, pp.1-9.
https://search.emarefa.net/detail/BIM-1063355
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1063355
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
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