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Cytotoxic Effects of Biosynthesized Zinc Oxide Nanoparticles on Murine Cell Lines
المؤلفون المشاركون
Rahman, Heshu Sulaiman
Azizi, Susan
Tahir, Paridah Mohd
Chartrand, Max Stanley
Mohammad, Rosfarizan
Namvar, Farideh
Yeap, Swee Keong
المصدر
Evidence-Based Complementary and Alternative Medicine
العدد
المجلد 2015، العدد 2015 (31 ديسمبر/كانون الأول 2015)، ص ص. 1-11، 11ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2015-02-16
دولة النشر
مصر
عدد الصفحات
11
التخصصات الرئيسية
الملخص EN
The aim of this study is to evaluate the in vitro cytotoxic activity and cellular effects of previously prepared ZnO-NPs on murine cancer cell lines using brown seaweed (Sargassum muticum) aqueous extract.
Treated cancer cells with ZnO-NPs for 72 hours demonstrated various levels of cytotoxicity based on calculated IC50 values using MTT assay as follows: 21.7 ± 1.3 μg/mL (4T1), 17.45 ± 1.1 μg/mL (CRL-1451), 11.75 ± 0.8 μg/mL (CT-26), and 5.6 ± 0.55 μg/mL (WEHI-3B), respectively.
On the other hand, ZnO-NPs treatments for 72 hours showed no toxicity against normal mouse fibroblast (3T3) cell line.
On the other hand, paclitaxel, which imposed an inhibitory effect on WEHI-3B cells with IC50 of 2.25 ± 0.4, 1.17 ± 0.5, and 1.6 ± 0.09 μg/mL after 24, 48, and 72 hours treatment, respectively, was used as positive control.
Furthermore, distinct morphological changes were found by utilizing fluorescent dyes; apoptotic population was increased via flowcytometry, while a cell cycle block and stimulation of apoptotic proteins were also observed.
Additionally, the present study showed that the caspase activations contributed to ZnO-NPs triggered apoptotic death in WEHI-3 cells.
Thus, the nature of biosynthesis and the therapeutic potential of ZnO-NPs could prepare the way for further research on the design of green synthesis therapeutic agents, particularly in nanomedicine, for the treatment of cancer.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Namvar, Farideh& Rahman, Heshu Sulaiman& Mohammad, Rosfarizan& Azizi, Susan& Tahir, Paridah Mohd& Chartrand, Max Stanley…[et al.]. 2015. Cytotoxic Effects of Biosynthesized Zinc Oxide Nanoparticles on Murine Cell Lines. Evidence-Based Complementary and Alternative Medicine،Vol. 2015, no. 2015, pp.1-11.
https://search.emarefa.net/detail/BIM-1063357
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Namvar, Farideh…[et al.]. Cytotoxic Effects of Biosynthesized Zinc Oxide Nanoparticles on Murine Cell Lines. Evidence-Based Complementary and Alternative Medicine No. 2015 (2015), pp.1-11.
https://search.emarefa.net/detail/BIM-1063357
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Namvar, Farideh& Rahman, Heshu Sulaiman& Mohammad, Rosfarizan& Azizi, Susan& Tahir, Paridah Mohd& Chartrand, Max Stanley…[et al.]. Cytotoxic Effects of Biosynthesized Zinc Oxide Nanoparticles on Murine Cell Lines. Evidence-Based Complementary and Alternative Medicine. 2015. Vol. 2015, no. 2015, pp.1-11.
https://search.emarefa.net/detail/BIM-1063357
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1063357
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
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