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Silymarin Accelerates Liver Regeneration after Partial Hepatectomy
المؤلفون المشاركون
Wu, Jia-Ping
Huang, Chih-Yang
Lin, Yueh-Min
Yeh, Yu-Lan
Lin, Chien-Chung
Day, Cecilia Hsuan
Shen, Chia-Yao
Padma, V. Vijaya
Pan, Lung-Fa
Tsai, Chin-Chuan
المصدر
Evidence-Based Complementary and Alternative Medicine
العدد
المجلد 2015، العدد 2015 (31 ديسمبر/كانون الأول 2015)، ص ص. 1-14، 14ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2015-08-03
دولة النشر
مصر
عدد الصفحات
14
التخصصات الرئيسية
الملخص EN
Partial hepatectomy (PHx) is a liver regeneration physiological response induced to maintain homeostasis.
Liver regeneration evolved presumably to protect wild animals from catastrophic liver loss caused by toxins or tissue injury.
Silymarin (Sm) ability to stimulate liver regeneration has been an object of curiosity for many years.
Silymarin has been investigated for use as an antioxidant and anticarcinogen.
However, its use as a supportive treatment for liver damage is elusive.
In this study, we fed silymarin (Sm, 25 mg/kg) to male Sprague-Dawley rats for 7 weeks.
Surgical 2/3 PHx was then conducted on the rats at 6 hrs, 24 hrs, and 72 hrs.
Western blot and RT-PCR were conducted to detect the cell cycle activities and silymarin effects on hepatic regeneration.
The results showed that silymarin enhanced liver regeneration by accelerating the cell cycle in PHx liver.
Silymarin led to increased G1 phase (cyclin D1/pRb), S phase (cyclin E/E2F), G2 phase (cyclin B), and M phase (cyclin A) protein and mRNA at 6 hrs, 24 hrs, and 72 hrs PHx.
HGF, TGFα, and TGFβ1 growth factor expressions were also enhanced.
We suggest that silymarin plays a crucial role in accelerated liver regeneration after PHx.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Wu, Jia-Ping& Tsai, Chin-Chuan& Yeh, Yu-Lan& Lin, Yueh-Min& Lin, Chien-Chung& Day, Cecilia Hsuan…[et al.]. 2015. Silymarin Accelerates Liver Regeneration after Partial Hepatectomy. Evidence-Based Complementary and Alternative Medicine،Vol. 2015, no. 2015, pp.1-14.
https://search.emarefa.net/detail/BIM-1063374
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Wu, Jia-Ping…[et al.]. Silymarin Accelerates Liver Regeneration after Partial Hepatectomy. Evidence-Based Complementary and Alternative Medicine No. 2015 (2015), pp.1-14.
https://search.emarefa.net/detail/BIM-1063374
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Wu, Jia-Ping& Tsai, Chin-Chuan& Yeh, Yu-Lan& Lin, Yueh-Min& Lin, Chien-Chung& Day, Cecilia Hsuan…[et al.]. Silymarin Accelerates Liver Regeneration after Partial Hepatectomy. Evidence-Based Complementary and Alternative Medicine. 2015. Vol. 2015, no. 2015, pp.1-14.
https://search.emarefa.net/detail/BIM-1063374
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1063374
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
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