Silymarin Accelerates Liver Regeneration after Partial Hepatectomy
Joint Authors
Wu, Jia-Ping
Huang, Chih-Yang
Lin, Yueh-Min
Yeh, Yu-Lan
Lin, Chien-Chung
Day, Cecilia Hsuan
Shen, Chia-Yao
Padma, V. Vijaya
Pan, Lung-Fa
Tsai, Chin-Chuan
Source
Evidence-Based Complementary and Alternative Medicine
Issue
Vol. 2015, Issue 2015 (31 Dec. 2015), pp.1-14, 14 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2015-08-03
Country of Publication
Egypt
No. of Pages
14
Main Subjects
Abstract EN
Partial hepatectomy (PHx) is a liver regeneration physiological response induced to maintain homeostasis.
Liver regeneration evolved presumably to protect wild animals from catastrophic liver loss caused by toxins or tissue injury.
Silymarin (Sm) ability to stimulate liver regeneration has been an object of curiosity for many years.
Silymarin has been investigated for use as an antioxidant and anticarcinogen.
However, its use as a supportive treatment for liver damage is elusive.
In this study, we fed silymarin (Sm, 25 mg/kg) to male Sprague-Dawley rats for 7 weeks.
Surgical 2/3 PHx was then conducted on the rats at 6 hrs, 24 hrs, and 72 hrs.
Western blot and RT-PCR were conducted to detect the cell cycle activities and silymarin effects on hepatic regeneration.
The results showed that silymarin enhanced liver regeneration by accelerating the cell cycle in PHx liver.
Silymarin led to increased G1 phase (cyclin D1/pRb), S phase (cyclin E/E2F), G2 phase (cyclin B), and M phase (cyclin A) protein and mRNA at 6 hrs, 24 hrs, and 72 hrs PHx.
HGF, TGFα, and TGFβ1 growth factor expressions were also enhanced.
We suggest that silymarin plays a crucial role in accelerated liver regeneration after PHx.
American Psychological Association (APA)
Wu, Jia-Ping& Tsai, Chin-Chuan& Yeh, Yu-Lan& Lin, Yueh-Min& Lin, Chien-Chung& Day, Cecilia Hsuan…[et al.]. 2015. Silymarin Accelerates Liver Regeneration after Partial Hepatectomy. Evidence-Based Complementary and Alternative Medicine،Vol. 2015, no. 2015, pp.1-14.
https://search.emarefa.net/detail/BIM-1063374
Modern Language Association (MLA)
Wu, Jia-Ping…[et al.]. Silymarin Accelerates Liver Regeneration after Partial Hepatectomy. Evidence-Based Complementary and Alternative Medicine No. 2015 (2015), pp.1-14.
https://search.emarefa.net/detail/BIM-1063374
American Medical Association (AMA)
Wu, Jia-Ping& Tsai, Chin-Chuan& Yeh, Yu-Lan& Lin, Yueh-Min& Lin, Chien-Chung& Day, Cecilia Hsuan…[et al.]. Silymarin Accelerates Liver Regeneration after Partial Hepatectomy. Evidence-Based Complementary and Alternative Medicine. 2015. Vol. 2015, no. 2015, pp.1-14.
https://search.emarefa.net/detail/BIM-1063374
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1063374