Effects of Green Tea Extracts on the Pharmacokinetics of Quetiapine in Rats

المؤلفون المشاركون

Asiri, Yousif A.
Iqbal, Muzaffar
Ezzeldin, Essam

المصدر

Evidence-Based Complementary and Alternative Medicine

العدد

المجلد 2015، العدد 2015 (31 ديسمبر/كانون الأول 2015)، ص ص. 1-4، 4ص.

الناشر

Hindawi Publishing Corporation

تاريخ النشر

2015-01-29

دولة النشر

مصر

عدد الصفحات

4

التخصصات الرئيسية

الطب البشري

الملخص EN

Quetiapine is an atypical antipsychotic, used clinically in the treatment of schizophrenia, acute mania in bipolar disorders, and bipolar depression in adults.

In this study, the effect of green tea extracts (GTE) on the pharmacokinetics of quetiapine (substrate of CYP3A4) was investigated in rats.

Male Wistar albino rats received GTE (175 mg/kg) or saline (control) by oral gavage for 7 days before a single intragastric administration of 25 mg/kg quetiapine.

Plasma concentrations of quetiapine were measured up to 12 h after its administration by a validated ultraperformance liquid chromatography-tandem mass spectroscopy.

Pretreatment with GTE produced significant reductions in the maximum plasma concentration and area under the curve of quetiapine by 45% and 35%, respectively, compared to quetiapine alone.

However, GTE did not produce significant change in elimination half-life and oral clearance of quetiapine.

This study concluded that GTE may decrease the bioavailability of quetiapine when coadministered.

نمط استشهاد جمعية علماء النفس الأمريكية (APA)

Ezzeldin, Essam& Asiri, Yousif A.& Iqbal, Muzaffar. 2015. Effects of Green Tea Extracts on the Pharmacokinetics of Quetiapine in Rats. Evidence-Based Complementary and Alternative Medicine،Vol. 2015, no. 2015, pp.1-4.
https://search.emarefa.net/detail/BIM-1063383

نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)

Ezzeldin, Essam…[et al.]. Effects of Green Tea Extracts on the Pharmacokinetics of Quetiapine in Rats. Evidence-Based Complementary and Alternative Medicine No. 2015 (2015), pp.1-4.
https://search.emarefa.net/detail/BIM-1063383

نمط استشهاد الجمعية الطبية الأمريكية (AMA)

Ezzeldin, Essam& Asiri, Yousif A.& Iqbal, Muzaffar. Effects of Green Tea Extracts on the Pharmacokinetics of Quetiapine in Rats. Evidence-Based Complementary and Alternative Medicine. 2015. Vol. 2015, no. 2015, pp.1-4.
https://search.emarefa.net/detail/BIM-1063383

نوع البيانات

مقالات

لغة النص

الإنجليزية

الملاحظات

Includes bibliographical references

رقم السجل

BIM-1063383