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Effects of Green Tea Extracts on the Pharmacokinetics of Quetiapine in Rats
Joint Authors
Asiri, Yousif A.
Iqbal, Muzaffar
Ezzeldin, Essam
Source
Evidence-Based Complementary and Alternative Medicine
Issue
Vol. 2015, Issue 2015 (31 Dec. 2015), pp.1-4, 4 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2015-01-29
Country of Publication
Egypt
No. of Pages
4
Main Subjects
Abstract EN
Quetiapine is an atypical antipsychotic, used clinically in the treatment of schizophrenia, acute mania in bipolar disorders, and bipolar depression in adults.
In this study, the effect of green tea extracts (GTE) on the pharmacokinetics of quetiapine (substrate of CYP3A4) was investigated in rats.
Male Wistar albino rats received GTE (175 mg/kg) or saline (control) by oral gavage for 7 days before a single intragastric administration of 25 mg/kg quetiapine.
Plasma concentrations of quetiapine were measured up to 12 h after its administration by a validated ultraperformance liquid chromatography-tandem mass spectroscopy.
Pretreatment with GTE produced significant reductions in the maximum plasma concentration and area under the curve of quetiapine by 45% and 35%, respectively, compared to quetiapine alone.
However, GTE did not produce significant change in elimination half-life and oral clearance of quetiapine.
This study concluded that GTE may decrease the bioavailability of quetiapine when coadministered.
American Psychological Association (APA)
Ezzeldin, Essam& Asiri, Yousif A.& Iqbal, Muzaffar. 2015. Effects of Green Tea Extracts on the Pharmacokinetics of Quetiapine in Rats. Evidence-Based Complementary and Alternative Medicine،Vol. 2015, no. 2015, pp.1-4.
https://search.emarefa.net/detail/BIM-1063383
Modern Language Association (MLA)
Ezzeldin, Essam…[et al.]. Effects of Green Tea Extracts on the Pharmacokinetics of Quetiapine in Rats. Evidence-Based Complementary and Alternative Medicine No. 2015 (2015), pp.1-4.
https://search.emarefa.net/detail/BIM-1063383
American Medical Association (AMA)
Ezzeldin, Essam& Asiri, Yousif A.& Iqbal, Muzaffar. Effects of Green Tea Extracts on the Pharmacokinetics of Quetiapine in Rats. Evidence-Based Complementary and Alternative Medicine. 2015. Vol. 2015, no. 2015, pp.1-4.
https://search.emarefa.net/detail/BIM-1063383
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1063383