Effect of α-Allocryptopine on Delayed Afterdepolarizations and Triggered Activities in Mice Cardiomyocytes Treated with Isoproterenol
المؤلفون المشاركون
Li, Yang
Xu, Bin
Fu, Yicheng
Liu, Li
Lin, Kun
Zhao, Xiaojing
Zhang, Yu
Chen, Xi
Cai, Zhongqi
Huang, Yun
المصدر
Evidence-Based Complementary and Alternative Medicine
العدد
المجلد 2015، العدد 2015 (31 ديسمبر/كانون الأول 2015)، ص ص. 1-9، 9ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2015-10-19
دولة النشر
مصر
عدد الصفحات
9
التخصصات الرئيسية
الملخص EN
Objective.
To investigate the effect of α-allocryptopine (ALL) on delayed afterdepolarization (DAD) incidence and triggered activity (TA) in mice administered isoproterenol (ISO).
Methods.
Mouse ventricular myocytes were isolated.
And the cellular electrophysiological properties of ventricular myocytes were investigated.
Results.
We found that the incidences of DADs and TA in mouse myocytes were increased by ISO treatment.
In sharp contrast, triggered arrhythmia events were rarely observed in myocytes with 10 μM ALL treatment.
Transient inward current (Iti) was reduced significantly with ALL treatment, which contributed to DAD-related triggered arrhythmia.
Compared to Iso-treated group, the L-type calcium current (ICa,L) densities were decreased after exposure to ALL, along with slower activation, quicker inactivation, and longer time constant of recovery from inactivation kinetics.
Conclusion.
There is less triggered arrhythmia events in ventricular myocytes treated with ALL.
This effect may be associated with the inhibition of Iti and ICa,L.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Xu, Bin& Fu, Yicheng& Liu, Li& Lin, Kun& Zhao, Xiaojing& Zhang, Yu…[et al.]. 2015. Effect of α-Allocryptopine on Delayed Afterdepolarizations and Triggered Activities in Mice Cardiomyocytes Treated with Isoproterenol. Evidence-Based Complementary and Alternative Medicine،Vol. 2015, no. 2015, pp.1-9.
https://search.emarefa.net/detail/BIM-1063408
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Xu, Bin…[et al.]. Effect of α-Allocryptopine on Delayed Afterdepolarizations and Triggered Activities in Mice Cardiomyocytes Treated with Isoproterenol. Evidence-Based Complementary and Alternative Medicine No. 2015 (2015), pp.1-9.
https://search.emarefa.net/detail/BIM-1063408
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Xu, Bin& Fu, Yicheng& Liu, Li& Lin, Kun& Zhao, Xiaojing& Zhang, Yu…[et al.]. Effect of α-Allocryptopine on Delayed Afterdepolarizations and Triggered Activities in Mice Cardiomyocytes Treated with Isoproterenol. Evidence-Based Complementary and Alternative Medicine. 2015. Vol. 2015, no. 2015, pp.1-9.
https://search.emarefa.net/detail/BIM-1063408
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1063408
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر