Effect of α-Allocryptopine on Delayed Afterdepolarizations and Triggered Activities in Mice Cardiomyocytes Treated with Isoproterenol
Joint Authors
Li, Yang
Xu, Bin
Fu, Yicheng
Liu, Li
Lin, Kun
Zhao, Xiaojing
Zhang, Yu
Chen, Xi
Cai, Zhongqi
Huang, Yun
Source
Evidence-Based Complementary and Alternative Medicine
Issue
Vol. 2015, Issue 2015 (31 Dec. 2015), pp.1-9, 9 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2015-10-19
Country of Publication
Egypt
No. of Pages
9
Main Subjects
Abstract EN
Objective.
To investigate the effect of α-allocryptopine (ALL) on delayed afterdepolarization (DAD) incidence and triggered activity (TA) in mice administered isoproterenol (ISO).
Methods.
Mouse ventricular myocytes were isolated.
And the cellular electrophysiological properties of ventricular myocytes were investigated.
Results.
We found that the incidences of DADs and TA in mouse myocytes were increased by ISO treatment.
In sharp contrast, triggered arrhythmia events were rarely observed in myocytes with 10 μM ALL treatment.
Transient inward current (Iti) was reduced significantly with ALL treatment, which contributed to DAD-related triggered arrhythmia.
Compared to Iso-treated group, the L-type calcium current (ICa,L) densities were decreased after exposure to ALL, along with slower activation, quicker inactivation, and longer time constant of recovery from inactivation kinetics.
Conclusion.
There is less triggered arrhythmia events in ventricular myocytes treated with ALL.
This effect may be associated with the inhibition of Iti and ICa,L.
American Psychological Association (APA)
Xu, Bin& Fu, Yicheng& Liu, Li& Lin, Kun& Zhao, Xiaojing& Zhang, Yu…[et al.]. 2015. Effect of α-Allocryptopine on Delayed Afterdepolarizations and Triggered Activities in Mice Cardiomyocytes Treated with Isoproterenol. Evidence-Based Complementary and Alternative Medicine،Vol. 2015, no. 2015, pp.1-9.
https://search.emarefa.net/detail/BIM-1063408
Modern Language Association (MLA)
Xu, Bin…[et al.]. Effect of α-Allocryptopine on Delayed Afterdepolarizations and Triggered Activities in Mice Cardiomyocytes Treated with Isoproterenol. Evidence-Based Complementary and Alternative Medicine No. 2015 (2015), pp.1-9.
https://search.emarefa.net/detail/BIM-1063408
American Medical Association (AMA)
Xu, Bin& Fu, Yicheng& Liu, Li& Lin, Kun& Zhao, Xiaojing& Zhang, Yu…[et al.]. Effect of α-Allocryptopine on Delayed Afterdepolarizations and Triggered Activities in Mice Cardiomyocytes Treated with Isoproterenol. Evidence-Based Complementary and Alternative Medicine. 2015. Vol. 2015, no. 2015, pp.1-9.
https://search.emarefa.net/detail/BIM-1063408
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1063408