Plumbagin Ameliorates CCl4-Induced Hepatic Fibrosis in Rats via the Epidermal Growth Factor Receptor Signaling Pathway
المؤلفون المشاركون
Chen, Si
Chen, Yi
Chen, Bi
Cai, Yi-jing
Zou, Zhuo-lin
Wang, Jin-guo
Lin, Zhuo
Wang, Xiao-dong
Fu, Li-yun
Hu, Yao-ren
Chen, Yong-ping
Chen, Da-zhi
المصدر
Evidence-Based Complementary and Alternative Medicine
العدد
المجلد 2015، العدد 2015 (31 ديسمبر/كانون الأول 2015)، ص ص. 1-12، 12ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2015-10-15
دولة النشر
مصر
عدد الصفحات
12
التخصصات الرئيسية
الملخص EN
Epidermal growth factor (EGF) and its signaling molecules, EGFreceptor (EGFR) and signal transducer and activator of transcription factor 3 (STAT3), have been considered to play a role in liver fibrosis and cirrhosis.
Plumbagin (PL) is an extracted component from the plant and has been used to treat different kinds of cancer.
However, its role in regulation of EGFR and STAT3 during liver fibrosis has not been investigated.
In this study, the effects of PL on the regulation of EGFR and STAT3 were investigated in carbon tetrachloride (CCl4) induced liver fibrosis and hepatic stellate cells (HSC-T6).
PL significantly attenuated liver injury and fibrosis in CCl4 treated rats.
At concentrations of 2 to 6 μM, PL did not induce significant cytotoxicity of HSC-T6 cells.
Moreover, PL reduced phosphorylation of EGFR and STAT3 in both fibrotic liver and heparin-binding EGF-like growth factor (HB-EGF) treated HSC-T6 cells.
Furthermore, PL reduced the expression of α-SMA, EGFR, and STAT3 in both fibrotic liver and HB-EGF treated HSC-T6 cells.
In conclusion, plumbagin could ameliorate the development of hepatic fibrosis through its downregulation of EGFR and STAT3 in the liver, especially in hepatic stellate cells.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Chen, Si& Chen, Yi& Chen, Bi& Cai, Yi-jing& Zou, Zhuo-lin& Wang, Jin-guo…[et al.]. 2015. Plumbagin Ameliorates CCl4-Induced Hepatic Fibrosis in Rats via the Epidermal Growth Factor Receptor Signaling Pathway. Evidence-Based Complementary and Alternative Medicine،Vol. 2015, no. 2015, pp.1-12.
https://search.emarefa.net/detail/BIM-1063426
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Chen, Si…[et al.]. Plumbagin Ameliorates CCl4-Induced Hepatic Fibrosis in Rats via the Epidermal Growth Factor Receptor Signaling Pathway. Evidence-Based Complementary and Alternative Medicine No. 2015 (2015), pp.1-12.
https://search.emarefa.net/detail/BIM-1063426
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Chen, Si& Chen, Yi& Chen, Bi& Cai, Yi-jing& Zou, Zhuo-lin& Wang, Jin-guo…[et al.]. Plumbagin Ameliorates CCl4-Induced Hepatic Fibrosis in Rats via the Epidermal Growth Factor Receptor Signaling Pathway. Evidence-Based Complementary and Alternative Medicine. 2015. Vol. 2015, no. 2015, pp.1-12.
https://search.emarefa.net/detail/BIM-1063426
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1063426
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر